node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUD13 | TEX29 | ENSP00000260210 | ENSP00000283547 | BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family | Testis-expressed protein 29; Testis expressed 29 | 0.501 |
C1orf106 | TEX29 | ENSP00000392105 | ENSP00000283547 | Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion | Testis-expressed protein 29; Testis expressed 29 | 0.543 |
C1orf106 | TMEM120B | ENSP00000392105 | ENSP00000404991 | Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion | Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | 0.400 |
MDGA1 | TEX29 | ENSP00000402584 | ENSP00000283547 | MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2; I-set domain containing | Testis-expressed protein 29; Testis expressed 29 | 0.529 |
MICAL2 | TEX29 | ENSP00000256194 | ENSP00000283547 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum- mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promot [...] | Testis-expressed protein 29; Testis expressed 29 | 0.463 |
PLGRKT | TEX29 | ENSP00000223864 | ENSP00000283547 | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | Testis-expressed protein 29; Testis expressed 29 | 0.528 |
SLC28A3 | TEX29 | ENSP00000365413 | ENSP00000283547 | Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine; Solute carriers | Testis-expressed protein 29; Testis expressed 29 | 0.438 |
TEX29 | BUD13 | ENSP00000283547 | ENSP00000260210 | Testis-expressed protein 29; Testis expressed 29 | BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family | 0.501 |
TEX29 | C1orf106 | ENSP00000283547 | ENSP00000392105 | Testis-expressed protein 29; Testis expressed 29 | Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion | 0.543 |
TEX29 | MDGA1 | ENSP00000283547 | ENSP00000402584 | Testis-expressed protein 29; Testis expressed 29 | MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2; I-set domain containing | 0.529 |
TEX29 | MICAL2 | ENSP00000283547 | ENSP00000256194 | Testis-expressed protein 29; Testis expressed 29 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum- mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promot [...] | 0.463 |
TEX29 | PLGRKT | ENSP00000283547 | ENSP00000223864 | Testis-expressed protein 29; Testis expressed 29 | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9 | 0.528 |
TEX29 | SLC28A3 | ENSP00000283547 | ENSP00000365413 | Testis-expressed protein 29; Testis expressed 29 | Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2-1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3’-azido-3’-deoxythymidine (AZT), ribavirin and 3-deazauridine; Solute carriers | 0.438 |
TEX29 | THSD4 | ENSP00000283547 | ENSP00000347484 | Testis-expressed protein 29; Testis expressed 29 | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like | 0.433 |
TEX29 | TMEM120B | ENSP00000283547 | ENSP00000404991 | Testis-expressed protein 29; Testis expressed 29 | Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | 0.618 |
TEX29 | UST | ENSP00000283547 | ENSP00000356433 | Testis-expressed protein 29; Testis expressed 29 | Uronyl 2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin; Sulfotransferases, membrane bound | 0.460 |
TEX29 | ZFAND3 | ENSP00000283547 | ENSP00000287218 | Testis-expressed protein 29; Testis expressed 29 | Zinc finger AN1-type containing 3 | 0.537 |
THSD4 | TEX29 | ENSP00000347484 | ENSP00000283547 | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity); ADAMTS like | Testis-expressed protein 29; Testis expressed 29 | 0.433 |
TMEM120B | C1orf106 | ENSP00000404991 | ENSP00000392105 | Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF- kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion | 0.400 |
TMEM120B | TEX29 | ENSP00000404991 | ENSP00000283547 | Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | Testis-expressed protein 29; Testis expressed 29 | 0.618 |