PLEKHG4B protein (human) - STRING database

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PLEKHG4B

Pleckstrin homology and RhoGEF domain containing G4B (1271 aa)

Predicted Functional Partners:

PLEKHG7

0.794

ALS2CL

0.633

GART

0.620

IGDCC3

0.605

DDX31

0.536

GTF3C5

0.491

SWAP70

0.489

SDK2

0.484

PRTG

0.479

DCC

0.463

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS2CL	PLEKHG4B	ENSP00000313670	ENSP00000283426	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics; VPS9 domain containing	Pleckstrin homology and RhoGEF domain containing G4B	0.633
ALS2CL	PLEKHG7	ENSP00000313670	ENSP00000344961	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics; VPS9 domain containing	Pleckstrin homology and RhoGEF domain containing G7	0.411
DCC	PLEKHG4B	ENSP00000389140	ENSP00000283426	Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing	Pleckstrin homology and RhoGEF domain containing G4B	0.463
DDX31	GTF3C5	ENSP00000361232	ENSP00000361180	Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily	General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors	0.650
DDX31	PLEKHG4B	ENSP00000361232	ENSP00000283426	Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily	Pleckstrin homology and RhoGEF domain containing G4B	0.536
GART	PLEKHG4B	ENSP00000371253	ENSP00000283426	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	Pleckstrin homology and RhoGEF domain containing G4B	0.620
GTF3C5	DDX31	ENSP00000361180	ENSP00000361232	General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors	Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily	0.650
GTF3C5	PLEKHG4B	ENSP00000361180	ENSP00000283426	General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors	Pleckstrin homology and RhoGEF domain containing G4B	0.491
IGDCC3	PLEKHG4B	ENSP00000332773	ENSP00000283426	Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing	Pleckstrin homology and RhoGEF domain containing G4B	0.605
IGDCC3	SDK2	ENSP00000332773	ENSP00000376421	Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing	Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing	0.446
PLEKHG4B	ALS2CL	ENSP00000283426	ENSP00000313670	Pleckstrin homology and RhoGEF domain containing G4B	ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics; VPS9 domain containing	0.633
PLEKHG4B	DCC	ENSP00000283426	ENSP00000389140	Pleckstrin homology and RhoGEF domain containing G4B	Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene; Fibronectin type III domain containing	0.463
PLEKHG4B	DDX31	ENSP00000283426	ENSP00000361232	Pleckstrin homology and RhoGEF domain containing G4B	Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily	0.536
PLEKHG4B	GART	ENSP00000283426	ENSP00000371253	Pleckstrin homology and RhoGEF domain containing G4B	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	0.620
PLEKHG4B	GTF3C5	ENSP00000283426	ENSP00000361180	Pleckstrin homology and RhoGEF domain containing G4B	General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors	0.491
PLEKHG4B	IGDCC3	ENSP00000283426	ENSP00000332773	Pleckstrin homology and RhoGEF domain containing G4B	Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing	0.605
PLEKHG4B	PLEKHG7	ENSP00000283426	ENSP00000344961	Pleckstrin homology and RhoGEF domain containing G4B	Pleckstrin homology and RhoGEF domain containing G7	0.794
PLEKHG4B	PRTG	ENSP00000283426	ENSP00000373937	Pleckstrin homology and RhoGEF domain containing G4B	Protogenin; May play a role in anteroposterior axis elongation; Fibronectin type III domain containing	0.479
PLEKHG4B	SDK2	ENSP00000283426	ENSP00000376421	Pleckstrin homology and RhoGEF domain containing G4B	Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing	0.484
PLEKHG4B	SWAP70	ENSP00000283426	ENSP00000315630	Pleckstrin homology and RhoGEF domain containing G4B	Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity); EF-hand domain containing	0.489

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