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  • 11.0 [archived version]
STRINGSTRING
WDR27 WDR27 CMTM8 CMTM8 KIF25 KIF25 CCDC155 CCDC155 B3GALT4 B3GALT4 FRMD1 FRMD1 MAATS1 MAATS1 WWC1 WWC1 NF2 NF2 WWC2 WWC2 FRMD6 FRMD6
"FRMD1" - FERM domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
FRMD1FERM domain containing 1 (549 aa)    
Predicted Functional Partners:
WWC1
Protein KIBRA; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migrati [...] (1119 aa)
     
  0.930
NF2
Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] (595 aa)
       
0.879
FRMD6
FERM domain containing 6 (622 aa)
         
0.811
WWC2
Protein WWC2; WW and C2 domain containing 2 (1192 aa)
     
 
  0.745
KIF25
Kinesin-like protein KIF25; Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase. Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis. May also act as a negative regulator of amino acid starvation-induced autophagy; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family (384 aa)
           
  0.713
CCDC155
Protein KASH5; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2-KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redunda [...] (562 aa)
           
  0.701
CMTM8
CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
           
  0.694
MAATS1
Cilia- and flagella-associated protein 91; May regulate cilium motility through its role in the assembly of the axonemal radial spokes (767 aa)
           
  0.676
WDR27
WD repeat-containing protein 27; WD repeat domain containing (895 aa)
           
  0.672
B3GALT4
Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis; Beta 3-glycosyltransferases (378 aa)
           
  0.655
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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