• Version:
  • 11.0 [archived version]
STRINGSTRING
UGDH UGDH GMPPB GMPPB EXT2 EXT2 EXTL3 EXTL3 UXS1 UXS1 XYLT1 XYLT1 SLC35B2 SLC35B2 UNC50 UNC50 FAM20B FAM20B XYLT2 XYLT2 B3GAT3 B3GAT3
"UXS1" - UDP-glucuronic acid decarboxylase 1 in Homo sapiens
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Predicted Interactions
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textmining
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protein homology
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UXS1UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis; Short chain dehydrogenase/reductase superfamily (425 aa)    
Predicted Functional Partners:
UGDH
UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate (494 aa)
 
  0.994
B3GAT3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4- Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta- [...] (335 aa)
     
   
  0.830
XYLT1
Xylosyltransferase 1; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes; Belongs to the glycosyltransferase 14 family. XylT subfamily (959 aa)
     
   
  0.789
FAM20B
Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] (409 aa)
           
  0.787
GMPPB
Mannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids; Belongs to the transferase hexapeptide repeat family (387 aa)
   
   
  0.730
SLC35B2
Adenosine 3’-phospho 5’-phosphosulfate transporter 1; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF- kappa-B and MAPK pathways; Solute carriers (432 aa)
     
   
  0.730
EXT2
Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (751 aa)
           
  0.728
UNC50
Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity) (259 aa)
           
  0.715
XYLT2
Xylosyltransferase 2; Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans. Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated; Belongs to the glycosyltransferase 14 family. XylT subfamily (865 aa)
     
   
  0.688
EXTL3
Exostosin-like 3; Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (919 aa)
           
  0.676
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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