RIOK2 protein (human) - STRING database

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RIOK2

Serine/threonine-protein kinase RIO2; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre- ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its catalytic activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA (552 aa)

Predicted Functional Partners:

TSR1

0.999

BYSL

0.999

PNO1

0.999

NOB1

0.999

LTV1

0.999

RPS15

0.998

RPS5

0.998

RPS8

0.997

RPS14

0.996

RPS13

0.996

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BYSL	LTV1	ENSP00000230340	ENSP00000356548	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	0.999
BYSL	NOB1	ENSP00000230340	ENSP00000268802	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family	0.999
BYSL	PNO1	ENSP00000230340	ENSP00000263657	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA	0.999
BYSL	RIOK2	ENSP00000230340	ENSP00000283109	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Serine/threonine-protein kinase RIO2; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre- ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its catalytic activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA	0.999
BYSL	RPS13	ENSP00000230340	ENSP00000435777	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ribosomal protein S13	0.996
BYSL	RPS14	ENSP00000230340	ENSP00000385958	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ribosomal protein S14	0.996
BYSL	RPS15	ENSP00000230340	ENSP00000467466	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ribosomal protein S15	0.997
BYSL	RPS5	ENSP00000230340	ENSP00000472985	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family	0.997
BYSL	RPS8	ENSP00000230340	ENSP00000379888	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family	0.997
BYSL	TSR1	ENSP00000230340	ENSP00000301364	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus	0.999
LTV1	BYSL	ENSP00000356548	ENSP00000230340	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	0.999
LTV1	NOB1	ENSP00000356548	ENSP00000268802	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family	0.999
LTV1	PNO1	ENSP00000356548	ENSP00000263657	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA	0.999
LTV1	RIOK2	ENSP00000356548	ENSP00000283109	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Serine/threonine-protein kinase RIO2; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre- ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its catalytic activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA	0.999
LTV1	RPS13	ENSP00000356548	ENSP00000435777	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Ribosomal protein S13	0.996
LTV1	RPS14	ENSP00000356548	ENSP00000385958	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Ribosomal protein S14	0.998
LTV1	RPS15	ENSP00000356548	ENSP00000467466	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Ribosomal protein S15	0.998
LTV1	RPS5	ENSP00000356548	ENSP00000472985	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family	0.997
LTV1	RPS8	ENSP00000356548	ENSP00000379888	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family	0.998
LTV1	TSR1	ENSP00000356548	ENSP00000301364	Protein LTV1 homolog; LTV1 ribosome biogenesis factor	Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus	0.999

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