| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP10B | KRT84 | ENSP00000313600 | ENSP00000257951 | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | Keratin, type II cuticular Hb4; Keratins, type II | 0.456 |
| ATP10B | RASA4B | ENSP00000313600 | ENSP00000440982 | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | 0.575 |
| ATP10B | TEKT5 | ENSP00000313600 | ENSP00000283025 | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.542 |
| ATP10B | VEPH1 | ENSP00000313600 | ENSP00000354919 | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.486 |
| CCDC172 | TEKT5 | ENSP00000329860 | ENSP00000283025 | Coiled-coil domain containing 172 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.626 |
| CCDC78 | TEKT5 | ENSP00000293889 | ENSP00000283025 | Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.485 |
| EFHC1 | TEKT5 | ENSP00000360107 | ENSP00000283025 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.548 |
| EFHC2 | TEKT5 | ENSP00000404232 | ENSP00000283025 | EF-hand domain-containing family member C2; EF-hand domain containing 2 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.583 |
| KRT84 | ATP10B | ENSP00000257951 | ENSP00000313600 | Keratin, type II cuticular Hb4; Keratins, type II | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | 0.456 |
| KRT84 | RASA4B | ENSP00000257951 | ENSP00000440982 | Keratin, type II cuticular Hb4; Keratins, type II | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | 0.536 |
| KRT84 | TEKT5 | ENSP00000257951 | ENSP00000283025 | Keratin, type II cuticular Hb4; Keratins, type II | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.503 |
| KRT84 | VEPH1 | ENSP00000257951 | ENSP00000354919 | Keratin, type II cuticular Hb4; Keratins, type II | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.447 |
| RASA4B | ATP10B | ENSP00000440982 | ENSP00000313600 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | 0.575 |
| RASA4B | KRT84 | ENSP00000440982 | ENSP00000257951 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Keratin, type II cuticular Hb4; Keratins, type II | 0.536 |
| RASA4B | TEKT5 | ENSP00000440982 | ENSP00000283025 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Tektin-5; May be a structural component of the sperm flagellum; Tektins | 0.549 |
| RASA4B | VEPH1 | ENSP00000440982 | ENSP00000354919 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing | 0.572 |
| TEKT5 | ATP10B | ENSP00000283025 | ENSP00000313600 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily | 0.542 |
| TEKT5 | CCDC172 | ENSP00000283025 | ENSP00000329860 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | Coiled-coil domain containing 172 | 0.626 |
| TEKT5 | CCDC78 | ENSP00000283025 | ENSP00000293889 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome | 0.485 |
| TEKT5 | EFHC1 | ENSP00000283025 | ENSP00000360107 | Tektin-5; May be a structural component of the sperm flagellum; Tektins | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | 0.548 |
