node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT11 | C1orf109 | ENSP00000360366 | ENSP00000350704 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | 0.841 |
ACOT11 | CWC25 | ENSP00000360366 | ENSP00000478070 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.841 |
ACOT11 | FAM26D | ENSP00000360366 | ENSP00000385836 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel | 0.841 |
ACOT11 | KIAA0226L | ENSP00000360366 | ENSP00000396935 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Protein RUBCNL-like; May act as a tumor suppressor | 0.841 |
ACOT11 | LIX1 | ENSP00000360366 | ENSP00000274382 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family | 0.841 |
ACOT11 | MOCS3 | ENSP00000360366 | ENSP00000244051 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide t [...] | 0.838 |
ACOT11 | PGM2 | ENSP00000360366 | ENSP00000371393 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity; Belongs to the phosphohexose mutase family | 0.844 |
ACOT11 | SHD | ENSP00000360366 | ENSP00000446058 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | SH2 domain-containing adapter protein D; May function as an adapter protein; SH2 domain containing | 0.839 |
ACOT11 | SLCO1A2 | ENSP00000360366 | ENSP00000305974 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin; Solute carriers | 0.893 |
ACOT11 | UGT3A2 | ENSP00000360366 | ENSP00000282507 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family | 0.697 |
C1orf109 | ACOT11 | ENSP00000350704 | ENSP00000360366 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates | 0.841 |
C1orf109 | CWC25 | ENSP00000350704 | ENSP00000478070 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex | 0.841 |
C1orf109 | FAM26D | ENSP00000350704 | ENSP00000385836 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel | 0.841 |
C1orf109 | KIAA0226L | ENSP00000350704 | ENSP00000396935 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Protein RUBCNL-like; May act as a tumor suppressor | 0.841 |
C1orf109 | LIX1 | ENSP00000350704 | ENSP00000274382 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family | 0.841 |
C1orf109 | MOCS3 | ENSP00000350704 | ENSP00000244051 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide t [...] | 0.839 |
C1orf109 | PGM2 | ENSP00000350704 | ENSP00000371393 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity; Belongs to the phosphohexose mutase family | 0.841 |
C1orf109 | SHD | ENSP00000350704 | ENSP00000446058 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | SH2 domain-containing adapter protein D; May function as an adapter protein; SH2 domain containing | 0.840 |
C1orf109 | SLCO1A2 | ENSP00000350704 | ENSP00000305974 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin; Solute carriers | 0.841 |
C1orf109 | UGT3A2 | ENSP00000350704 | ENSP00000282507 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition | UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family | 0.697 |