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  • 11.0 [archived version]
STRINGSTRING
SHD SHD UGT3A2 UGT3A2 CWC25 CWC25 KIAA0226L KIAA0226L PGM2 PGM2 FAM26D FAM26D ACOT11 ACOT11 LIX1 LIX1 C1orf109 C1orf109 SLCO1A2 SLCO1A2 MOCS3 MOCS3
"UGT3A2" - UDP-glucuronosyltransferase 3A2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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UGT3A2UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family (523 aa)    
Predicted Functional Partners:
SLCO1A2
Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin; Solute carriers (670 aa)
     
   
  0.707
ACOT11
Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (607 aa)
     
   
  0.697
CWC25
CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex (425 aa)
     
        0.697
KIAA0226L
Protein RUBCNL-like; May act as a tumor suppressor (662 aa)
     
        0.697
FAM26D
Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel (171 aa)
     
        0.697
PGM2
Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity; Belongs to the phosphohexose mutase family (612 aa)
     
        0.697
C1orf109
Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition (203 aa)
     
        0.697
LIX1
Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family (282 aa)
     
        0.697
MOCS3
Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide t [...] (460 aa)
     
   
  0.684
SHD
SH2 domain-containing adapter protein D; May function as an adapter protein; SH2 domain containing (340 aa)
     
        0.679
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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