node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AXL | ZSCAN1 | ENSP00000301178 | ENSP00000282326 | Tyrosine-protein kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidate [...] | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.600 |
EIF2AK1 | ZSCAN1 | ENSP00000199389 | ENSP00000282326 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.623 |
GATA1 | ZSCAN1 | ENSP00000365858 | ENSP00000282326 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5’-[AT]GATA[AG]-3’ within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS; GATA zinc finger domain containing | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.574 |
GGH | ZSCAN1 | ENSP00000260118 | ENSP00000282326 | Gamma-glutamyl hydrolase; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates; Belongs to the peptidase C26 family | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.628 |
PGBD1 | ZNF174 | ENSP00000259883 | ENSP00000268655 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.823 |
PGBD1 | ZNF213 | ENSP00000259883 | ENSP00000380087 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 213; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.862 |
PGBD1 | ZNF24 | ENSP00000259883 | ENSP00000261332 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.828 |
PGBD1 | ZSCAN1 | ENSP00000259883 | ENSP00000282326 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.828 |
PGBD1 | ZSCAN18 | ENSP00000259883 | ENSP00000470123 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation; SCAN domain containing | 0.823 |
PLVAP | ZSCAN1 | ENSP00000252590 | ENSP00000282326 | Plasmalemma vesicle-associated protein; Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.711 |
ZNF174 | PGBD1 | ENSP00000268655 | ENSP00000259883 | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | 0.823 |
ZNF174 | ZNF24 | ENSP00000268655 | ENSP00000261332 | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.890 |
ZNF174 | ZSCAN1 | ENSP00000268655 | ENSP00000282326 | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.694 |
ZNF174 | ZSCAN18 | ENSP00000268655 | ENSP00000470123 | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation; SCAN domain containing | 0.766 |
ZNF213 | PGBD1 | ENSP00000380087 | ENSP00000259883 | Zinc finger protein 213; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | 0.862 |
ZNF213 | ZSCAN1 | ENSP00000380087 | ENSP00000282326 | Zinc finger protein 213; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.710 |
ZNF24 | PGBD1 | ENSP00000261332 | ENSP00000259883 | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | 0.828 |
ZNF24 | ZNF174 | ENSP00000261332 | ENSP00000268655 | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.890 |
ZNF24 | ZSCAN1 | ENSP00000261332 | ENSP00000282326 | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | 0.645 |
ZSCAN1 | AXL | ENSP00000282326 | ENSP00000301178 | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing | Tyrosine-protein kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidate [...] | 0.600 |