node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GUCY1A2 | GUCY1A3 | ENSP00000282249 | ENSP00000296518 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | 0.820 |
GUCY1A2 | GUCY1B3 | ENSP00000282249 | ENSP00000264424 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | 0.986 |
GUCY1A2 | ITPA | ENSP00000282249 | ENSP00000369456 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2’-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5’-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions | 0.904 |
GUCY1A2 | MOCS1 | ENSP00000282249 | ENSP00000362282 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’-triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family | 0.808 |
GUCY1A2 | NUDT2 | ENSP00000282249 | ENSP00000368455 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Bis(5’-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis; Belongs to the Nudix hydrolase family | 0.900 |
GUCY1A2 | PDE1A | ENSP00000282249 | ENSP00000410309 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | Calcium/calmodulin-dependent 3’,5’-cyclic nucleotide phosphodiesterase 1A; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP; Phosphodiesterases | 0.856 |
GUCY1A2 | PDE2A | ENSP00000282249 | ENSP00000334910 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | cGMP-dependent 3’,5’-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) | 0.832 |
GUCY1A2 | PDE9A | ENSP00000282249 | ENSP00000291539 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | High affinity cGMP-specific 3’,5’-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific- compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ab [...] | 0.813 |
GUCY1A2 | PRKG1 | ENSP00000282249 | ENSP00000363092 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] | 0.918 |
GUCY1A2 | PRKG2 | ENSP00000282249 | ENSP00000264399 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK [...] | 0.919 |
GUCY1A3 | GUCY1A2 | ENSP00000296518 | ENSP00000282249 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.820 |
GUCY1A3 | GUCY1B3 | ENSP00000296518 | ENSP00000264424 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | 0.999 |
GUCY1A3 | ITPA | ENSP00000296518 | ENSP00000369456 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2’-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5’-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions | 0.910 |
GUCY1A3 | MOCS1 | ENSP00000296518 | ENSP00000362282 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’-triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family | 0.801 |
GUCY1A3 | NUDT2 | ENSP00000296518 | ENSP00000368455 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Bis(5’-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis; Belongs to the Nudix hydrolase family | 0.900 |
GUCY1A3 | PDE1A | ENSP00000296518 | ENSP00000410309 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Calcium/calmodulin-dependent 3’,5’-cyclic nucleotide phosphodiesterase 1A; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP; Phosphodiesterases | 0.783 |
GUCY1A3 | PDE2A | ENSP00000296518 | ENSP00000334910 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | cGMP-dependent 3’,5’-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) | 0.775 |
GUCY1A3 | PDE9A | ENSP00000296518 | ENSP00000291539 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | High affinity cGMP-specific 3’,5’-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific- compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ab [...] | 0.787 |
GUCY1A3 | PRKG1 | ENSP00000296518 | ENSP00000363092 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] | 0.907 |
GUCY1A3 | PRKG2 | ENSP00000296518 | ENSP00000264399 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK [...] | 0.912 |