node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIB1 | GUF1 | ENSP00000479860 | ENSP00000281543 | Calcium and integrin binding 1; EF-hand domain containing | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | 0.910 |
GUF1 | CIB1 | ENSP00000281543 | ENSP00000479860 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Calcium and integrin binding 1; EF-hand domain containing | 0.910 |
GUF1 | MRPL13 | ENSP00000281543 | ENSP00000306548 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | 0.885 |
GUF1 | MRPL19 | ENSP00000281543 | ENSP00000377486 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family | 0.876 |
GUF1 | MRPL20 | ENSP00000281543 | ENSP00000341082 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein L20 | 0.895 |
GUF1 | MRPS11 | ENSP00000281543 | ENSP00000317376 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein S11 | 0.852 |
GUF1 | MRPS7 | ENSP00000281543 | ENSP00000245539 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.869 |
GUF1 | MRPS9 | ENSP00000281543 | ENSP00000258455 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | Mitochondrial ribosomal protein S9 | 0.887 |
GUF1 | RPL11 | ENSP00000281543 | ENSP00000363676 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] | 0.843 |
GUF1 | RPL9 | ENSP00000281543 | ENSP00000400467 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | L ribosomal proteins | 0.836 |
GUF1 | RPS3 | ENSP00000281543 | ENSP00000278572 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein [...] | 0.838 |
MRPL13 | GUF1 | ENSP00000306548 | ENSP00000281543 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily | 0.885 |
MRPL13 | MRPL19 | ENSP00000306548 | ENSP00000377486 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family | 0.999 |
MRPL13 | MRPL20 | ENSP00000306548 | ENSP00000341082 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Mitochondrial ribosomal protein L20 | 0.998 |
MRPL13 | MRPS11 | ENSP00000306548 | ENSP00000317376 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Mitochondrial ribosomal protein S11 | 0.998 |
MRPL13 | MRPS7 | ENSP00000306548 | ENSP00000245539 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.999 |
MRPL13 | MRPS9 | ENSP00000306548 | ENSP00000258455 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | Mitochondrial ribosomal protein S9 | 0.999 |
MRPL13 | RPL11 | ENSP00000306548 | ENSP00000363676 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] | 0.939 |
MRPL13 | RPL9 | ENSP00000306548 | ENSP00000400467 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | L ribosomal proteins | 0.942 |
MRPL13 | RPS3 | ENSP00000306548 | ENSP00000278572 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein [...] | 0.943 |