| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMN | AMN1 | ENSP00000299155 | ENSP00000281471 | Protein amnionless; Necessary for efficient absorption of vitamin B12. Required for normal CUBN- mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | 0.612 |
| AMN1 | AMN | ENSP00000281471 | ENSP00000299155 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Protein amnionless; Necessary for efficient absorption of vitamin B12. Required for normal CUBN- mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity) | 0.612 |
| AMN1 | CEP76 | ENSP00000281471 | ENSP00000262127 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | 0.636 |
| AMN1 | ENSG00000272772 | ENSP00000281471 | ENSP00000430774 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Uncharacterized protein; Belongs to the SKP1 family | 0.773 |
| AMN1 | FERMT2 | ENSP00000281471 | ENSP00000342858 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] | 0.600 |
| AMN1 | PSMC6 | ENSP00000281471 | ENSP00000401802 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | 26S proteasome regulatory subunit 10B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated wi [...] | 0.657 |
| AMN1 | PSMF1 | ENSP00000281471 | ENSP00000338039 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28; Belongs to the proteasome inhibitor PI31 family | 0.657 |
| AMN1 | SCCPDH | ENSP00000281471 | ENSP00000355467 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Saccharopine dehydrogenase-like oxidoreductase; Saccharopine dehydrogenase; Belongs to the saccharopine dehydrogenase family | 0.608 |
| AMN1 | SMPD2 | ENSP00000281471 | ENSP00000258052 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF; Belongs to the neutral sphingomyelinase family | 0.662 |
| AMN1 | TLK2 | ENSP00000281471 | ENSP00000316512 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy | 0.719 |
| AMN1 | VARS | ENSP00000281471 | ENSP00000364815 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | Valine--tRNA ligase; Aminoacyl tRNA synthetases, Class I | 0.585 |
| CEP76 | AMN1 | ENSP00000262127 | ENSP00000281471 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | 0.636 |
| CEP76 | FERMT2 | ENSP00000262127 | ENSP00000342858 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] | 0.475 |
| CEP76 | PSMC6 | ENSP00000262127 | ENSP00000401802 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | 26S proteasome regulatory subunit 10B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated wi [...] | 0.467 |
| CEP76 | PSMF1 | ENSP00000262127 | ENSP00000338039 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28; Belongs to the proteasome inhibitor PI31 family | 0.431 |
| CEP76 | SMPD2 | ENSP00000262127 | ENSP00000258052 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF; Belongs to the neutral sphingomyelinase family | 0.504 |
| CEP76 | TLK2 | ENSP00000262127 | ENSP00000316512 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy | 0.603 |
| ENSG00000272772 | AMN1 | ENSP00000430774 | ENSP00000281471 | Uncharacterized protein; Belongs to the SKP1 family | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | 0.773 |
| FERMT2 | AMN1 | ENSP00000342858 | ENSP00000281471 | Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog | 0.600 |
| FERMT2 | CEP76 | ENSP00000342858 | ENSP00000262127 | Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication; Belongs to the CEP76 family | 0.475 |
