CGNL1 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CGNL1

Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (1302 aa)

Predicted Functional Partners:

TMOD3

0.901

TMOD2

0.746

CYP19A1

0.711

PLEKHA7

0.694

CLDN12

0.670

EEA1

0.630

LAMP1

0.582

CLDN3

0.560

TIAM1

0.554

RACGAP1

0.547

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGNL1	CLDN12	ENSP00000281282	ENSP00000287916	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.670
CGNL1	CLDN3	ENSP00000281282	ENSP00000378577	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family	0.560
CGNL1	CYP19A1	ENSP00000281282	ENSP00000379683	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Cytochrome P450 family 19	0.711
CGNL1	EEA1	ENSP00000281282	ENSP00000317955	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking; Zinc fingers FYVE-type	0.630
CGNL1	LAMP1	ENSP00000281282	ENSP00000333298	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.582
CGNL1	PLEKHA7	ENSP00000281282	ENSP00000347883	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site; Pleckstrin homology domain containing	0.694
CGNL1	RACGAP1	ENSP00000281282	ENSP00000404190	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Rac GTPase-activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogene [...]	0.547
CGNL1	TIAM1	ENSP00000281282	ENSP00000286827	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	T-lymphoma invasion and metastasis-inducing protein 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration; PDZ domain containing	0.554
CGNL1	TMOD2	ENSP00000281282	ENSP00000249700	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Tropomodulins	0.746
CGNL1	TMOD3	ENSP00000281282	ENSP00000308753	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Belongs to the tropomodulin family	0.901
CLDN12	CGNL1	ENSP00000287916	ENSP00000281282	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	0.670
CLDN12	CLDN3	ENSP00000287916	ENSP00000378577	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family	0.979
CLDN3	CGNL1	ENSP00000378577	ENSP00000281282	Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	0.560
CLDN3	CLDN12	ENSP00000378577	ENSP00000287916	Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.979
CYP19A1	CGNL1	ENSP00000379683	ENSP00000281282	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Cytochrome P450 family 19	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	0.711
CYP19A1	TMOD2	ENSP00000379683	ENSP00000249700	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Cytochrome P450 family 19	Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Tropomodulins	0.504
CYP19A1	TMOD3	ENSP00000379683	ENSP00000308753	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Cytochrome P450 family 19	Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Belongs to the tropomodulin family	0.729
EEA1	CGNL1	ENSP00000317955	ENSP00000281282	Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking; Zinc fingers FYVE-type	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	0.630
EEA1	LAMP1	ENSP00000317955	ENSP00000333298	Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking; Zinc fingers FYVE-type	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.909
LAMP1	CGNL1	ENSP00000333298	ENSP00000281282	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons	0.582

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About