| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABTB1 | BTBD11 | ENSP00000232744 | ENSP00000280758 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.562 |
| ABTB1 | CUL1 | ENSP00000232744 | ENSP00000326804 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | 0.865 |
| ABTB1 | FBXL19 | ENSP00000232744 | ENSP00000369666 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.575 |
| ASNSD1 | BTBD11 | ENSP00000260952 | ENSP00000280758 | Asparagine synthetase domain containing 1 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.579 |
| BTBD11 | ABTB1 | ENSP00000280758 | ENSP00000232744 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing | 0.562 |
| BTBD11 | ASNSD1 | ENSP00000280758 | ENSP00000260952 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Asparagine synthetase domain containing 1 | 0.579 |
| BTBD11 | C12orf5 | ENSP00000280758 | ENSP00000179259 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | 0.582 |
| BTBD11 | CUL1 | ENSP00000280758 | ENSP00000326804 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | 0.550 |
| BTBD11 | FBXL19 | ENSP00000280758 | ENSP00000369666 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.562 |
| BTBD11 | GSTT2B | ENSP00000280758 | ENSP00000290765 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Glutathione S-transferase theta-2B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity; Soluble glutathione S-transferases | 0.621 |
| BTBD11 | NUAK1 | ENSP00000280758 | ENSP00000261402 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | NUAK family SNF1-like kinase 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of ’Ser-464’ of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1- phosphorylated PPP [...] | 0.569 |
| BTBD11 | PPFIBP1 | ENSP00000280758 | ENSP00000314724 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | 0.781 |
| BTBD11 | STAB2 | ENSP00000280758 | ENSP00000373539 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily [...] | 0.582 |
| BTBD11 | TSPAN9 | ENSP00000280758 | ENSP00000011898 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.654 |
| C12orf5 | BTBD11 | ENSP00000179259 | ENSP00000280758 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.582 |
| C12orf5 | PPFIBP1 | ENSP00000179259 | ENSP00000314724 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing | 0.551 |
| C12orf5 | TSPAN9 | ENSP00000179259 | ENSP00000011898 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a [...] | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family | 0.651 |
| CUL1 | ABTB1 | ENSP00000326804 | ENSP00000232744 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing | 0.865 |
| CUL1 | BTBD11 | ENSP00000326804 | ENSP00000280758 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing | 0.550 |
| CUL1 | FBXL19 | ENSP00000326804 | ENSP00000369666 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the [...] | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.979 |
