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  • 11.0 [archived version]
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RPS28 RPS28 RPL37A RPL37A ENSG00000270800 ENSG00000270800 FAU FAU DEPDC7 DEPDC7 KCNAB3 KCNAB3 KCNA3 KCNA3 KCNA6 KCNA6 KCNAB2 KCNAB2 KCNAB1 KCNAB1 AMIGO1 AMIGO1
"KCNA6" - Potassium voltage-gated channel subfamily A member 6 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KCNA6Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; [...] (529 aa)    
Predicted Functional Partners:
FAU
Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion (133 aa)
     
 
  0.788
KCNAB2
Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5 [...] (415 aa)
     
 
  0.701
ENSG00000270800
RPS10-NUDT3 readthrough (286 aa)
     
 
  0.661
KCNAB3
Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5; Aldo-keto reductases (404 aa)
     
 
  0.587
KCNA3
Potassium voltage-gated channel subfamily A member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Potassium voltage-gated channels (575 aa)
   
 
0.560
AMIGO1
Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the immunoglobulin superfamil [...] (493 aa)
       
 
  0.538
DEPDC7
DEP domain containing 7; Belongs to the DEPDC7 family (511 aa)
           
  0.529
KCNAB1
Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the clos [...] (419 aa)
     
 
  0.524
RPL37A
Ribosomal protein L37a (92 aa)
     
 
  0.503
RPS28
Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family (69 aa)
     
 
  0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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