node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16orf93 | FAM53A | ENSP00000437532 | ENSP00000310057 | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.669 |
C16orf93 | PRSS53 | ENSP00000437532 | ENSP00000280606 | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.623 |
FAM53A | C16orf93 | ENSP00000310057 | ENSP00000437532 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | 0.669 |
FAM53A | PRSS53 | ENSP00000310057 | ENSP00000280606 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.461 |
FGA | PRSS53 | ENSP00000306361 | ENSP00000280606 | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it i [...] | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.686 |
G6PC2 | PRSS53 | ENSP00000364512 | ENSP00000280606 | Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Glucose 6-phosphatases, catalytic | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.470 |
G6PC2 | TMEM229B | ENSP00000364512 | ENSP00000350050 | Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Glucose 6-phosphatases, catalytic | Transmembrane protein 229B | 0.404 |
HOXD13 | PRSS53 | ENSP00000376322 | ENSP00000280606 | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity); Belongs to the Abd-B homeobox family | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.572 |
KRT36 | PRSS53 | ENSP00000329165 | ENSP00000280606 | Keratin, type I cuticular Ha6; Keratins, type I | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.511 |
LCE3D | PRSS53 | ENSP00000357776 | ENSP00000280606 | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | 0.440 |
LCE3D | TCHHL1 | ENSP00000357776 | ENSP00000357796 | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | S100 fused type protein family; Belongs to the S-100 family | 0.429 |
PRSS53 | C16orf93 | ENSP00000280606 | ENSP00000437532 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 | 0.623 |
PRSS53 | FAM53A | ENSP00000280606 | ENSP00000310057 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle | 0.461 |
PRSS53 | FGA | ENSP00000280606 | ENSP00000306361 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it i [...] | 0.686 |
PRSS53 | G6PC2 | ENSP00000280606 | ENSP00000364512 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Glucose 6-phosphatases, catalytic | 0.470 |
PRSS53 | HOXD13 | ENSP00000280606 | ENSP00000376322 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity); Belongs to the Abd-B homeobox family | 0.572 |
PRSS53 | KRT36 | ENSP00000280606 | ENSP00000329165 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Keratin, type I cuticular Ha6; Keratins, type I | 0.511 |
PRSS53 | LCE3D | ENSP00000280606 | ENSP00000357776 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family | 0.440 |
PRSS53 | TCHHL1 | ENSP00000280606 | ENSP00000357796 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | S100 fused type protein family; Belongs to the S-100 family | 0.428 |
PRSS53 | TMEM229B | ENSP00000280606 | ENSP00000350050 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases | Transmembrane protein 229B | 0.658 |