• Version:
  • 11.0 [archived version]
STRINGSTRING
FAM53A FAM53A C16orf93 C16orf93 VKORC1 VKORC1 HOXD13 HOXD13 TCHHL1 TCHHL1 PRSS53 PRSS53 G6PC2 G6PC2 TMEM229B TMEM229B LCE3D LCE3D FGA FGA KRT36 KRT36
"PRSS53" - Serine protease 53 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PRSS53Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases (553 aa)    
Predicted Functional Partners:
FGA
Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it i [...] (866 aa)
       
 
  0.686
TMEM229B
Transmembrane protein 229B (167 aa)
           
  0.658
C16orf93
Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 (331 aa)
           
  0.623
HOXD13
Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity); Belongs to the Abd-B homeobox family (343 aa)
           
  0.572
KRT36
Keratin, type I cuticular Ha6; Keratins, type I (467 aa)
           
  0.511
VKORC1
Vitamin K epoxide reductase complex subunit 1; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (163 aa)
 
 
   
  0.477
G6PC2
Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity); Glucose 6-phosphatases, catalytic (355 aa)
           
  0.470
FAM53A
Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle (398 aa)
           
  0.461
LCE3D
Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family (92 aa)
           
  0.440
TCHHL1
S100 fused type protein family; Belongs to the S-100 family (904 aa)
           
  0.428
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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