• Version:
  • 11.0 [archived version]
STRINGSTRING
UBE4A UBE4A ENSG00000086848 ENSG00000086848 C11orf57 C11orf57 DIBD1 DIBD1 METTL24 METTL24 PIH1D2 PIH1D2 RPAP3 RPAP3 RUVBL1 RUVBL1 SPAG1 SPAG1 RUVBL2 RUVBL2 SUGT1 SUGT1
"PIH1D2" - PIH1 domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIH1D2PIH1 domain containing 2; Belongs to the PIH1 family (315 aa)    
Predicted Functional Partners:
C11orf57
Uncharacterized protein NKAPD1; Chromosome 11 open reading frame 57 (293 aa)
           
  0.776
SPAG1
Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity; Tetratricopeptide repeat domain containing (926 aa)
     
 
  0.733
RUVBL1
RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases (456 aa)
     
 
  0.708
RUVBL2
RuvB-like 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes; Belongs to the RuvB family (463 aa)
     
 
  0.699
RPAP3
RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation; Belongs to the RPAP3 family (665 aa)
     
 
  0.590
METTL24
Methyltransferase-like protein 24; Methyltransferase like 24 (366 aa)
           
  0.552
ENSG00000086848
Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family (844 aa)
           
  0.545
DIBD1
Mannosyltransferase; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family (618 aa)
           
  0.537
UBE4A
Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates ’Lys-48’-linked polyubiquitination of substrates; Armadillo-like helical domain containing (1073 aa)
           
  0.533
SUGT1
Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins (365 aa)
     
 
  0.500
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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