| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSMD3 | DPH6 | ENSP00000297405 | ENSP00000256538 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.623 |
| CSMD3 | HYDIN | ENSP00000297405 | ENSP00000377197 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.634 |
| CSMD3 | LDLRAD3 | ENSP00000297405 | ENSP00000318607 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | 0.688 |
| CSMD3 | MYO3B | ENSP00000297405 | ENSP00000386213 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.611 |
| CSMD3 | PPP1R1C | ENSP00000297405 | ENSP00000280295 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis | 0.613 |
| DPH6 | CSMD3 | ENSP00000256538 | ENSP00000297405 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.623 |
| DPH6 | HYDIN | ENSP00000256538 | ENSP00000377197 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.629 |
| DPH6 | LDLRAD3 | ENSP00000256538 | ENSP00000318607 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | 0.608 |
| DPH6 | MYO3B | ENSP00000256538 | ENSP00000386213 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.658 |
| DPH6 | PPP1R1C | ENSP00000256538 | ENSP00000280295 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis | 0.659 |
| DUSP3 | PPP1R1C | ENSP00000226004 | ENSP00000280295 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis | 0.553 |
| FAM19A4 | PPP1R1C | ENSP00000295569 | ENSP00000280295 | Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis | 0.537 |
| HYDIN | CSMD3 | ENSP00000377197 | ENSP00000297405 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.634 |
| HYDIN | DPH6 | ENSP00000377197 | ENSP00000256538 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.629 |
| HYDIN | LDLRAD3 | ENSP00000377197 | ENSP00000318607 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | 0.621 |
| HYDIN | MYO3B | ENSP00000377197 | ENSP00000386213 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.614 |
| HYDIN | PPP1R1C | ENSP00000377197 | ENSP00000280295 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis | 0.625 |
| LDLRAD3 | CSMD3 | ENSP00000318607 | ENSP00000297405 | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.688 |
| LDLRAD3 | DPH6 | ENSP00000318607 | ENSP00000256538 | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.608 |
| LDLRAD3 | HYDIN | ENSP00000318607 | ENSP00000377197 | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.621 |
