| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP3 | AKAP4 | ENSP00000228850 | ENSP00000351327 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | 0.453 |
| AKAP3 | FSIP1 | ENSP00000228850 | ENSP00000280236 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | 0.660 |
| AKAP3 | FSIP2 | ENSP00000228850 | ENSP00000344403 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | Fibrous sheath interacting protein 2 | 0.663 |
| AKAP3 | ROPN1 | ENSP00000228850 | ENSP00000184183 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation; Belongs to the ropporin family | 0.943 |
| AKAP4 | AKAP3 | ENSP00000351327 | ENSP00000228850 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | 0.453 |
| AKAP4 | FSIP1 | ENSP00000351327 | ENSP00000280236 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | 0.818 |
| AKAP4 | FSIP2 | ENSP00000351327 | ENSP00000344403 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | Fibrous sheath interacting protein 2 | 0.803 |
| AKAP4 | ROPN1 | ENSP00000351327 | ENSP00000184183 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation; Belongs to the ropporin family | 0.697 |
| DHRS11 | FSIP1 | ENSP00000482704 | ENSP00000280236 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta- pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | 0.757 |
| DHRS11 | HADH | ENSP00000482704 | ENSP00000474560 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta- pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family | 0.509 |
| DHRS11 | HSD17B10 | ENSP00000482704 | ENSP00000168216 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta- pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] | 3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structur [...] | 0.721 |
| DHRS11 | RIBC1 | ENSP00000482704 | ENSP00000364476 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta- pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.403 |
| FSIP1 | AKAP3 | ENSP00000280236 | ENSP00000228850 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins | 0.660 |
| FSIP1 | AKAP4 | ENSP00000280236 | ENSP00000351327 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | 0.818 |
| FSIP1 | DHRS11 | ENSP00000280236 | ENSP00000482704 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta- pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] | 0.757 |
| FSIP1 | FSIP2 | ENSP00000280236 | ENSP00000344403 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | Fibrous sheath interacting protein 2 | 0.810 |
| FSIP1 | HADH | ENSP00000280236 | ENSP00000474560 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family | 0.630 |
| FSIP1 | HSD17B10 | ENSP00000280236 | ENSP00000168216 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | 3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structur [...] | 0.834 |
| FSIP1 | KIAA0391 | ENSP00000280236 | ENSP00000440915 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | Mitochondrial ribonuclease P catalytic subunit; Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5’-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5’-ends | 0.669 |
| FSIP1 | RIBC1 | ENSP00000280236 | ENSP00000364476 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.655 |
