SPATA4 protein (human) - STRING database

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SPATA4

Spermatogenesis-associated protein 4; Spermatogenesis associated 4 (305 aa)

Predicted Functional Partners:

FANK1

0.735

TFAP2D

0.731

AGPAT5

0.704

MEIG1

0.690

MTUS1

0.669

OGFR

0.639

ZCCHC3

0.633

PMFBP1

0.618

WDR17

0.597

SPATA6L

0.579

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGPAT5	SPATA4	ENSP00000285518	ENSP00000280191	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15-0-C20-4 at the sn-1 position using C18-1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltra [...]	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.704
AGPAT5	TFAP2D	ENSP00000285518	ENSP00000008391	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15-0-C20-4 at the sn-1 position using C18-1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltra [...]	Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity)	0.576
AGPAT5	ZCCHC3	ENSP00000285518	ENSP00000484056	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15-0-C20-4 at the sn-1 position using C18-1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltra [...]	Zinc finger CCHC-type containing 3	0.511
FANK1	OGFR	ENSP00000357682	ENSP00000290291	Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing	Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation	0.566
FANK1	SPATA4	ENSP00000357682	ENSP00000280191	Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.735
MEIG1	SPATA4	ENSP00000384334	ENSP00000280191	Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.690
MTUS1	PMFBP1	ENSP00000262102	ENSP00000237353	Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family	Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton	0.690
MTUS1	SPATA4	ENSP00000262102	ENSP00000280191	Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.669
OGFR	FANK1	ENSP00000290291	ENSP00000357682	Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation	Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing	0.566
OGFR	SPATA4	ENSP00000290291	ENSP00000280191	Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.639
PMFBP1	MTUS1	ENSP00000237353	ENSP00000262102	Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton	Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family	0.690
PMFBP1	SPATA4	ENSP00000237353	ENSP00000280191	Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	0.618
SPATA4	AGPAT5	ENSP00000280191	ENSP00000285518	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15-0-C20-4 at the sn-1 position using C18-1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltra [...]	0.704
SPATA4	FANK1	ENSP00000280191	ENSP00000357682	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing	0.735
SPATA4	MEIG1	ENSP00000280191	ENSP00000384334	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis	0.690
SPATA4	MTUS1	ENSP00000280191	ENSP00000262102	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family	0.669
SPATA4	OGFR	ENSP00000280191	ENSP00000290291	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation	0.639
SPATA4	PMFBP1	ENSP00000280191	ENSP00000237353	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton	0.618
SPATA4	SPATA6L	ENSP00000280191	ENSP00000417063	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Spermatogenesis-associated 6-like protein; Spermatogenesis associated 6 like	0.579
SPATA4	TFAP2D	ENSP00000280191	ENSP00000008391	Spermatogenesis-associated protein 4; Spermatogenesis associated 4	Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity)	0.731

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