FAM124A protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FAM124A

Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family (582 aa)

Predicted Functional Partners:

RNASEH2B

0.750

DLEU7

0.715

BTBD9

0.709

DNAH8

0.689

WDR1

0.654

SLC2A9

0.646

QDPR

0.643

ZBTB45

0.558

C19orf47

0.558

ERCC6L2

0.554

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD9	DNAH8	ENSP00000418751	ENSP00000333363	BTB/POZ domain-containing protein 9; BTB domain containing 9	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	0.613
BTBD9	FAM124A	ENSP00000418751	ENSP00000280057	BTB/POZ domain-containing protein 9; BTB domain containing 9	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	0.709
BTBD9	RNASEH2B	ENSP00000418751	ENSP00000337623	BTB/POZ domain-containing protein 9; BTB domain containing 9	Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes	0.494
C19orf47	FAM124A	ENSP00000463159	ENSP00000280057	Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	0.558
C19orf47	ZBTB45	ENSP00000463159	ENSP00000469089	Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47	Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity); BTB domain containing	0.571
DLEU7	FAM124A	ENSP00000420976	ENSP00000280057	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	0.715
DLEU7	RNASEH2B	ENSP00000420976	ENSP00000337623	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes	0.600
DNAH8	BTBD9	ENSP00000333363	ENSP00000418751	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	BTB/POZ domain-containing protein 9; BTB domain containing 9	0.613
DNAH8	FAM124A	ENSP00000333363	ENSP00000280057	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	0.689
ERCC6L2	FAM124A	ENSP00000288985	ENSP00000280057	DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	0.554
FAM124A	BTBD9	ENSP00000280057	ENSP00000418751	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	BTB/POZ domain-containing protein 9; BTB domain containing 9	0.709
FAM124A	C19orf47	ENSP00000280057	ENSP00000463159	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47	0.558
FAM124A	DLEU7	ENSP00000280057	ENSP00000420976	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	0.715
FAM124A	DNAH8	ENSP00000280057	ENSP00000333363	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Dyneins, axonemal	0.689
FAM124A	ERCC6L2	ENSP00000280057	ENSP00000288985	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response	0.554
FAM124A	QDPR	ENSP00000280057	ENSP00000281243	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Short chain dehydrogenase/reductase superfamily	0.643
FAM124A	RNASEH2B	ENSP00000280057	ENSP00000337623	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes	0.750
FAM124A	SLC2A9	ENSP00000280057	ENSP00000264784	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Solute carrier family 2, facilitated glucose transporter member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate; Solute carriers	0.646
FAM124A	WDR1	ENSP00000280057	ENSP00000427687	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape chan [...]	0.654
FAM124A	ZBTB45	ENSP00000280057	ENSP00000469089	Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family	Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity); BTB domain containing	0.558

page 1 of 2

Network

Cooccurrence

Textmining

Neighborhood

Experiments

Fusion

Databases

Coexpression

© STRING Consortium 2020

Credits

Access

Info

About