SPINT4 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPINT4

Serine peptidase inhibitor, Kunitz type 4 (99 aa)

Predicted Functional Partners:

WFDC8

0.825

SEMG1

0.755

WFDC13

0.754

SEMG2

0.731

WFDC6

0.709

WFDC10B

0.701

WFDC9

0.686

WAP7

0.677

SPINT3

0.671

WFIKKN1

0.668

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEMG1	SEMG2	ENSP00000361867	ENSP00000361855	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.457
SEMG1	SPINT3	ENSP00000361867	ENSP00000217428	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	Serine peptidase inhibitor, Kunitz type 3	0.424
SEMG1	SPINT4	ENSP00000361867	ENSP00000279058	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	Serine peptidase inhibitor, Kunitz type 4	0.755
SEMG1	WAP7	ENSP00000361867	ENSP00000424176	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	EPPIN-WFDC6 readthrough; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility	0.724
SEMG1	WFDC6	ENSP00000361867	ENSP00000361755	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	WAP four-disulfide core domain containing	0.592
SEMG1	WFDC8	ENSP00000361867	ENSP00000361735	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	WAP four-disulfide core domain containing	0.780
SEMG1	WFDC9	ENSP00000361867	ENSP00000320532	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	Protein WFDC9; WAP four-disulfide core domain containing	0.520
SEMG2	SEMG1	ENSP00000361855	ENSP00000361867	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	0.457
SEMG2	SPINT3	ENSP00000361855	ENSP00000217428	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Serine peptidase inhibitor, Kunitz type 3	0.463
SEMG2	SPINT4	ENSP00000361855	ENSP00000279058	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	Serine peptidase inhibitor, Kunitz type 4	0.731
SEMG2	WAP7	ENSP00000361855	ENSP00000424176	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	EPPIN-WFDC6 readthrough; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility	0.496
SEMG2	WFDC6	ENSP00000361855	ENSP00000361755	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	WAP four-disulfide core domain containing	0.505
SEMG2	WFDC8	ENSP00000361855	ENSP00000361735	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	WAP four-disulfide core domain containing	0.769
SPINT3	SEMG1	ENSP00000217428	ENSP00000361867	Serine peptidase inhibitor, Kunitz type 3	Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA	0.424
SPINT3	SEMG2	ENSP00000217428	ENSP00000361855	Serine peptidase inhibitor, Kunitz type 3	Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa	0.463
SPINT3	SPINT4	ENSP00000217428	ENSP00000279058	Serine peptidase inhibitor, Kunitz type 3	Serine peptidase inhibitor, Kunitz type 4	0.671
SPINT3	WFDC10B	ENSP00000217428	ENSP00000337466	Serine peptidase inhibitor, Kunitz type 3	Protein WFDC10B; WAP four-disulfide core domain containing	0.653
SPINT3	WFDC13	ENSP00000217428	ENSP00000302938	Serine peptidase inhibitor, Kunitz type 3	WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing	0.595
SPINT3	WFDC8	ENSP00000217428	ENSP00000361735	Serine peptidase inhibitor, Kunitz type 3	WAP four-disulfide core domain containing	0.676
SPINT3	WFDC9	ENSP00000217428	ENSP00000320532	Serine peptidase inhibitor, Kunitz type 3	Protein WFDC9; WAP four-disulfide core domain containing	0.720

page 1 of 4

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About