| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP1M1 | MPZL2 | ENSP00000388996 | ENSP00000278937 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.573 |
| CREG1 | MPZL2 | ENSP00000359540 | ENSP00000278937 | Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R; Belongs to the CREG family | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.695 |
| CREG1 | NFKBID | ENSP00000359540 | ENSP00000380109 | Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R; Belongs to the CREG family | NF-kappa-B inhibitor delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity); Ankyrin repeat domain containing | 0.665 |
| EVA1C | MPZL2 | ENSP00000300255 | ENSP00000278937 | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.762 |
| EVC | MPZL2 | ENSP00000264956 | ENSP00000278937 | Ellis-van Creveld syndrome protein; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.541 |
| MPZL2 | AP1M1 | ENSP00000278937 | ENSP00000388996 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.573 |
| MPZL2 | CREG1 | ENSP00000278937 | ENSP00000359540 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R; Belongs to the CREG family | 0.695 |
| MPZL2 | EVA1C | ENSP00000278937 | ENSP00000300255 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family | 0.762 |
| MPZL2 | EVC | ENSP00000278937 | ENSP00000264956 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Ellis-van Creveld syndrome protein; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development | 0.541 |
| MPZL2 | MPZL3 | ENSP00000278937 | ENSP00000278949 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Myelin protein zero-like protein 3; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.631 |
| MPZL2 | NFKBID | ENSP00000278937 | ENSP00000380109 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | NF-kappa-B inhibitor delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity); Ankyrin repeat domain containing | 0.560 |
| MPZL2 | PALM3 | ENSP00000278937 | ENSP00000344996 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling | 0.551 |
| MPZL2 | PRDM16 | ENSP00000278937 | ENSP00000270722 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | PR domain zinc finger protein 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation; L [...] | 0.545 |
| MPZL2 | TMEM26 | ENSP00000278937 | ENSP00000382237 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Transmembrane protein 26 | 0.691 |
| MPZL2 | UCP1 | ENSP00000278937 | ENSP00000262999 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in [...] | 0.548 |
| MPZL3 | MPZL2 | ENSP00000278949 | ENSP00000278937 | Myelin protein zero-like protein 3; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.631 |
| NFKBID | CREG1 | ENSP00000380109 | ENSP00000359540 | NF-kappa-B inhibitor delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity); Ankyrin repeat domain containing | Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R; Belongs to the CREG family | 0.665 |
| NFKBID | MPZL2 | ENSP00000380109 | ENSP00000278937 | NF-kappa-B inhibitor delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes (By similarity); Ankyrin repeat domain containing | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.560 |
| PALM3 | MPZL2 | ENSP00000344996 | ENSP00000278937 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.551 |
| PRDM16 | MPZL2 | ENSP00000270722 | ENSP00000278937 | PR domain zinc finger protein 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation; L [...] | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family | 0.545 |
