| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLCA2 | ESAM | ENSP00000359596 | ENSP00000278927 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.751 |
| CLDN15 | CLDN3 | ENSP00000385300 | ENSP00000378577 | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | 0.909 |
| CLDN15 | CLDN5 | ENSP00000385300 | ENSP00000385477 | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.909 |
| CLDN15 | ESAM | ENSP00000385300 | ENSP00000278927 | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.688 |
| CLDN15 | OCLN | ENSP00000385300 | ENSP00000347379 | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions; Protein phosphatase 1 regulatory subunits | 0.857 |
| CLDN3 | CLDN15 | ENSP00000378577 | ENSP00000385300 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | 0.909 |
| CLDN3 | CLDN5 | ENSP00000378577 | ENSP00000385477 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.939 |
| CLDN3 | ESAM | ENSP00000378577 | ENSP00000278927 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.670 |
| CLDN3 | OCLN | ENSP00000378577 | ENSP00000347379 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions; Protein phosphatase 1 regulatory subunits | 0.947 |
| CLDN5 | CLDN15 | ENSP00000385477 | ENSP00000385300 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | 0.909 |
| CLDN5 | CLDN3 | ENSP00000385477 | ENSP00000378577 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | 0.939 |
| CLDN5 | ESAM | ENSP00000385477 | ENSP00000278927 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.828 |
| CLDN5 | OCLN | ENSP00000385477 | ENSP00000347379 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions; Protein phosphatase 1 regulatory subunits | 0.973 |
| CLDN5 | PECAM1 | ENSP00000385477 | ENSP00000457421 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viab [...] | 0.688 |
| DCBLD2 | ESAM | ENSP00000321573 | ENSP00000278927 | Discoidin, CUB and LCCL domain containing 2 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.745 |
| DCBLD2 | LRRC32 | ENSP00000321573 | ENSP00000384126 | Discoidin, CUB and LCCL domain containing 2 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.766 |
| ESAM | CLCA2 | ENSP00000278927 | ENSP00000359596 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.751 |
| ESAM | CLDN15 | ENSP00000278927 | ENSP00000385300 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | 0.688 |
| ESAM | CLDN3 | ENSP00000278927 | ENSP00000378577 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family | 0.670 |
| ESAM | CLDN5 | ENSP00000278927 | ENSP00000385477 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins | 0.828 |
