node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEP192 | CEP250 | ENSP00000427550 | ENSP00000380661 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | 0.941 |
CEP192 | NEDD1 | ENSP00000427550 | ENSP00000451211 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Protein NEDD1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle; WD repeat domain containing | 0.987 |
CEP192 | NEK2 | ENSP00000427550 | ENSP00000355966 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint [...] | 0.939 |
CEP192 | NINL | ENSP00000427550 | ENSP00000278886 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | 0.944 |
CEP192 | OFD1 | ENSP00000427550 | ENSP00000344314 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...] | 0.932 |
CEP192 | PCNT | ENSP00000427550 | ENSP00000352572 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.970 |
CEP192 | PLK1 | ENSP00000427550 | ENSP00000300093 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CC [...] | 0.966 |
CEP192 | TUBG1 | ENSP00000427550 | ENSP00000251413 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation; Tubulins | 0.917 |
CEP192 | TUBGCP4 | ENSP00000427550 | ENSP00000260383 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | Gamma-tubulin complex component 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.929 |
CEP192 | YWHAE | ENSP00000427550 | ENSP00000264335 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm; Belongs to the 14-3-3 family | 0.903 |
CEP250 | CEP192 | ENSP00000380661 | ENSP00000427550 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication; Protein phosphatase 1 regulatory subunits | 0.941 |
CEP250 | NEDD1 | ENSP00000380661 | ENSP00000451211 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Protein NEDD1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle; WD repeat domain containing | 0.918 |
CEP250 | NEK2 | ENSP00000380661 | ENSP00000355966 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint [...] | 0.995 |
CEP250 | NINL | ENSP00000380661 | ENSP00000278886 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | 0.937 |
CEP250 | OFD1 | ENSP00000380661 | ENSP00000344314 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...] | 0.960 |
CEP250 | PCNT | ENSP00000380661 | ENSP00000352572 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.953 |
CEP250 | PLK1 | ENSP00000380661 | ENSP00000300093 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CC [...] | 0.931 |
CEP250 | TUBG1 | ENSP00000380661 | ENSP00000251413 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation; Tubulins | 0.908 |
CEP250 | TUBGCP4 | ENSP00000380661 | ENSP00000260383 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Gamma-tubulin complex component 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.907 |
CEP250 | YWHAE | ENSP00000380661 | ENSP00000264335 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm; Belongs to the 14-3-3 family | 0.906 |