| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CADPS2 | CCDC82 | ENSP00000398481 | ENSP00000278520 | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | Coiled-coil domain containing 82 | 0.495 |
| CADPS2 | INPPL1 | ENSP00000398481 | ENSP00000298229 | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | 0.638 |
| CCDC82 | CADPS2 | ENSP00000278520 | ENSP00000398481 | Coiled-coil domain containing 82 | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | 0.495 |
| CCDC82 | INPPL1 | ENSP00000278520 | ENSP00000298229 | Coiled-coil domain containing 82 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | 0.638 |
| CCDC82 | LY6G6C | ENSP00000278520 | ENSP00000364978 | Coiled-coil domain containing 82 | Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing | 0.622 |
| CCDC82 | METTL5 | ENSP00000278520 | ENSP00000260953 | Coiled-coil domain containing 82 | Methyltransferase-like protein 5; Probable methyltransferase | 0.568 |
| CCDC82 | PUS7 | ENSP00000278520 | ENSP00000348722 | Coiled-coil domain containing 82 | Pseudouridylate synthase 7 | 0.479 |
| CCDC82 | RFX5 | ENSP00000278520 | ENSP00000290524 | Coiled-coil domain containing 82 | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | 0.725 |
| CCDC82 | SLC45A4 | ENSP00000278520 | ENSP00000428137 | Coiled-coil domain containing 82 | Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family | 0.498 |
| CCDC82 | TBC1D23 | ENSP00000278520 | ENSP00000377700 | Coiled-coil domain containing 82 | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but inste [...] | 0.497 |
| CCDC82 | THADA | ENSP00000278520 | ENSP00000385995 | Coiled-coil domain containing 82 | Thyroid adenoma-associated protein; THADA, armadillo repeat containing; Belongs to the THADA family | 0.713 |
| CCDC82 | TMC3 | ENSP00000278520 | ENSP00000352413 | Coiled-coil domain containing 82 | Transmembrane channel-like protein 3; Probable ion channel; Transmembrane channel likes | 0.539 |
| INPPL1 | CADPS2 | ENSP00000298229 | ENSP00000398481 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity); C2 domain containing | 0.638 |
| INPPL1 | CCDC82 | ENSP00000298229 | ENSP00000278520 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | Coiled-coil domain containing 82 | 0.638 |
| INPPL1 | RFX5 | ENSP00000298229 | ENSP00000290524 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | 0.404 |
| INPPL1 | THADA | ENSP00000298229 | ENSP00000385995 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalin [...] | Thyroid adenoma-associated protein; THADA, armadillo repeat containing; Belongs to the THADA family | 0.439 |
| LY6G6C | CCDC82 | ENSP00000364978 | ENSP00000278520 | Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing | Coiled-coil domain containing 82 | 0.622 |
| METTL5 | CCDC82 | ENSP00000260953 | ENSP00000278520 | Methyltransferase-like protein 5; Probable methyltransferase | Coiled-coil domain containing 82 | 0.568 |
| METTL5 | PUS7 | ENSP00000260953 | ENSP00000348722 | Methyltransferase-like protein 5; Probable methyltransferase | Pseudouridylate synthase 7 | 0.499 |
| METTL5 | SLC45A4 | ENSP00000260953 | ENSP00000428137 | Methyltransferase-like protein 5; Probable methyltransferase | Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family | 0.513 |
