node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAZ2A | ZNF214 | ENSP00000446880 | ENSP00000278314 | Bromodomain adjacent to zinc finger domain protein 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H [...] | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.699 |
BAZ2B | ZNF214 | ENSP00000376534 | ENSP00000278314 | Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.673 |
CDKN1C | ZNF214 | ENSP00000413720 | ENSP00000278314 | Cyclin-dependent kinase inhibitor 1C; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life; Belongs to the CDI family | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.549 |
OR10A3 | ZNF214 | ENSP00000353988 | ENSP00000278314 | Olfactory receptor 10A3; Odorant receptor; Olfactory receptors, family 10 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.621 |
OR10A4 | ZNF214 | ENSP00000369157 | ENSP00000278314 | Olfactory receptor 10A4; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 10 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.558 |
OR2D2 | ZNF214 | ENSP00000299459 | ENSP00000278314 | Olfactory receptor 2D2; Odorant receptor; Olfactory receptors, family 2 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.571 |
OR2D3 | ZNF214 | ENSP00000320560 | ENSP00000278314 | Olfactory receptor 2D3; Odorant receptor; Olfactory receptors, family 2 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.614 |
RIPPLY3 | ZNF214 | ENSP00000331734 | ENSP00000278314 | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.635 |
TOPORS | ZNF214 | ENSP00000353735 | ENSP00000278314 | E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation; Ring finger proteins | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.554 |
TRIM28 | ZNF214 | ENSP00000253024 | ENSP00000278314 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.904 |
ZNF214 | BAZ2A | ENSP00000278314 | ENSP00000446880 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Bromodomain adjacent to zinc finger domain protein 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H [...] | 0.699 |
ZNF214 | BAZ2B | ENSP00000278314 | ENSP00000376534 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family | 0.673 |
ZNF214 | CDKN1C | ENSP00000278314 | ENSP00000413720 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cyclin-dependent kinase inhibitor 1C; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life; Belongs to the CDI family | 0.549 |
ZNF214 | OR10A3 | ENSP00000278314 | ENSP00000353988 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Olfactory receptor 10A3; Odorant receptor; Olfactory receptors, family 10 | 0.621 |
ZNF214 | OR10A4 | ENSP00000278314 | ENSP00000369157 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Olfactory receptor 10A4; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 10 | 0.558 |
ZNF214 | OR2D2 | ENSP00000278314 | ENSP00000299459 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Olfactory receptor 2D2; Odorant receptor; Olfactory receptors, family 2 | 0.571 |
ZNF214 | OR2D3 | ENSP00000278314 | ENSP00000320560 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Olfactory receptor 2D3; Odorant receptor; Olfactory receptors, family 2 | 0.614 |
ZNF214 | RIPPLY3 | ENSP00000278314 | ENSP00000331734 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | 0.635 |
ZNF214 | TOPORS | ENSP00000278314 | ENSP00000353735 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation; Ring finger proteins | 0.554 |
ZNF214 | TRIM28 | ENSP00000278314 | ENSP00000253024 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.904 |