| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDKL5 | LRRC4C | ENSP00000369325 | ENSP00000278198 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | 0.750 |
| CDKL5 | NTNG1 | ENSP00000369325 | ENSP00000359085 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.660 |
| CDKL5 | NTNG2 | ENSP00000369325 | ENSP00000376921 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.514 |
| DFNB31 | LRRC4C | ENSP00000354623 | ENSP00000278198 | Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | 0.809 |
| DFNB31 | USH1G | ENSP00000354623 | ENSP00000480279 | Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear | Usher syndrome type-1G protein; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing; Ankyrin repeat domain containing | 0.873 |
| LPHN1 | LRRC4C | ENSP00000340688 | ENSP00000278198 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | 0.701 |
| LPHN1 | NLGN1 | ENSP00000340688 | ENSP00000392500 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and [...] | 0.402 |
| LPHN2 | LRRC4C | ENSP00000322270 | ENSP00000278198 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | 0.701 |
| LPHN3 | LRRC4C | ENSP00000422533 | ENSP00000278198 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | 0.740 |
| LRRC4C | CDKL5 | ENSP00000278198 | ENSP00000369325 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | 0.750 |
| LRRC4C | DFNB31 | ENSP00000278198 | ENSP00000354623 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear | 0.809 |
| LRRC4C | LPHN1 | ENSP00000278198 | ENSP00000340688 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.701 |
| LRRC4C | LPHN2 | ENSP00000278198 | ENSP00000322270 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.701 |
| LRRC4C | LPHN3 | ENSP00000278198 | ENSP00000422533 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.740 |
| LRRC4C | NLGN1 | ENSP00000278198 | ENSP00000392500 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and [...] | 0.745 |
| LRRC4C | NTNG1 | ENSP00000278198 | ENSP00000359085 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.988 |
| LRRC4C | NTNG2 | ENSP00000278198 | ENSP00000376921 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.904 |
| LRRC4C | TADA3 | ENSP00000278198 | ENSP00000307684 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4; Belongs to the NGG1 family | 0.748 |
| LRRC4C | USH1G | ENSP00000278198 | ENSP00000480279 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing | Usher syndrome type-1G protein; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing; Ankyrin repeat domain containing | 0.725 |
| NLGN1 | LPHN1 | ENSP00000392500 | ENSP00000340688 | Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and [...] | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.402 |
