| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL14 | ITPRIP | ENSP00000323847 | ENSP00000278071 | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells; ARF GTPase family | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.580 |
| ARL5B | ITPRIP | ENSP00000366487 | ENSP00000278071 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.505 |
| C10orf128 | ITPRIP | ENSP00000363268 | ENSP00000278071 | Putative uncharacterized protein C10orf128; Chromosome 10 open reading frame 128 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.503 |
| C10orf128 | TNRC6C | ENSP00000363268 | ENSP00000336783 | Putative uncharacterized protein C10orf128; Chromosome 10 open reading frame 128 | Trinucleotide repeat-containing gene 6C protein; Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4- NOT and PAN deadenylase complexes; Trinucleotide repeat containing | 0.641 |
| C12orf66 | ITPRIP | ENSP00000311486 | ENSP00000278071 | KICSTOR complex protein C12orf66; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.473 |
| C12orf66 | OR10H5 | ENSP00000311486 | ENSP00000310704 | KICSTOR complex protein C12orf66; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | Olfactory receptor 10H5; Odorant receptor; Olfactory receptors, family 10 | 0.587 |
| C2orf54 | ITPRIP | ENSP00000373586 | ENSP00000278071 | Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.474 |
| C2orf54 | TMEM102 | ENSP00000373586 | ENSP00000315387 | Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 | Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway | 0.475 |
| ITPR1 | ITPRIP | ENSP00000306253 | ENSP00000278071 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity); Inositol 1,4,5-triphosphate receptors | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.535 |
| ITPRIP | ARL14 | ENSP00000278071 | ENSP00000323847 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells; ARF GTPase family | 0.580 |
| ITPRIP | ARL5B | ENSP00000278071 | ENSP00000366487 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | 0.505 |
| ITPRIP | C10orf128 | ENSP00000278071 | ENSP00000363268 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Putative uncharacterized protein C10orf128; Chromosome 10 open reading frame 128 | 0.503 |
| ITPRIP | C12orf66 | ENSP00000278071 | ENSP00000311486 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | KICSTOR complex protein C12orf66; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose | 0.473 |
| ITPRIP | C2orf54 | ENSP00000278071 | ENSP00000373586 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 | 0.474 |
| ITPRIP | ITPR1 | ENSP00000278071 | ENSP00000306253 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity); Inositol 1,4,5-triphosphate receptors | 0.535 |
| ITPRIP | MAB21L3 | ENSP00000278071 | ENSP00000358512 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Protein mab-21-like 3; Mab-21 like 3 | 0.494 |
| ITPRIP | OR10H5 | ENSP00000278071 | ENSP00000310704 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Olfactory receptor 10H5; Odorant receptor; Olfactory receptors, family 10 | 0.559 |
| ITPRIP | TMEM102 | ENSP00000278071 | ENSP00000315387 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway | 0.482 |
| ITPRIP | TNRC6C | ENSP00000278071 | ENSP00000336783 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | Trinucleotide repeat-containing gene 6C protein; Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4- NOT and PAN deadenylase complexes; Trinucleotide repeat containing | 0.497 |
| MAB21L3 | ITPRIP | ENSP00000358512 | ENSP00000278071 | Protein mab-21-like 3; Mab-21 like 3 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family | 0.494 |
