FAM188A protein (human) - STRING database

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FAM188A

Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins (445 aa)

Predicted Functional Partners:

TMEM45A

0.738

CRADD

0.718

ARL6IP5

0.714

TMEM9

0.669

GKN2

0.669

PAMR1

0.658

SUGCT

0.609

UBL7

0.604

RWDD1

0.582

COPS7A

0.579

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL6IP5	COPS7A	ENSP00000273258	ENSP00000438115	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	0.540
ARL6IP5	FAM188A	ENSP00000273258	ENSP00000277632	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	0.714
ARL6IP5	SUGCT	ENSP00000273258	ENSP00000338475	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family	0.557
ARL6IP5	TMEM45A	ENSP00000273258	ENSP00000319009	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	Transmembrane protein 45A; Belongs to the TMEM45 family	0.430
COPS7A	ARL6IP5	ENSP00000438115	ENSP00000273258	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	0.540
COPS7A	FAM188A	ENSP00000438115	ENSP00000277632	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	0.579
COPS7A	GKN2	ENSP00000438115	ENSP00000329292	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	Gastrokine-2; BRICHOS domain containing	0.556
COPS7A	TMEM45A	ENSP00000438115	ENSP00000319009	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	Transmembrane protein 45A; Belongs to the TMEM45 family	0.556
COPS7A	TMEM9	ENSP00000438115	ENSP00000356301	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	Transmembrane protein 9; May be involved in intracellular transport	0.633
CRADD	FAM188A	ENSP00000439068	ENSP00000277632	Death domain-containing protein CRADD; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex; Caspase recruitment domain containing	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	0.718
FAM188A	ARL6IP5	ENSP00000277632	ENSP00000273258	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic; YIP family	0.714
FAM188A	COPS7A	ENSP00000277632	ENSP00000438115	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...]	0.579
FAM188A	CRADD	ENSP00000277632	ENSP00000439068	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Death domain-containing protein CRADD; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex; Caspase recruitment domain containing	0.718
FAM188A	GKN2	ENSP00000277632	ENSP00000329292	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Gastrokine-2; BRICHOS domain containing	0.669
FAM188A	PAMR1	ENSP00000277632	ENSP00000482899	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle; Belongs to the peptidase S1 family	0.658
FAM188A	RWDD1	ENSP00000277632	ENSP00000420357	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family	0.582
FAM188A	SUGCT	ENSP00000277632	ENSP00000338475	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family	0.609
FAM188A	TMEM45A	ENSP00000277632	ENSP00000319009	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Transmembrane protein 45A; Belongs to the TMEM45 family	0.738
FAM188A	TMEM9	ENSP00000277632	ENSP00000356301	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Transmembrane protein 9; May be involved in intracellular transport	0.669
FAM188A	UBL7	ENSP00000277632	ENSP00000457703	Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins	Ubiquitin-like protein 7; Ubiquitin like 7	0.604

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