| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1QTNF9 | GSDMC | ENSP00000371503 | ENSP00000276708 | Complement C1q and tumor necrosis factor-related protein 9A; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity); C1q and TNF related | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.470 |
| CLMN | GSDMC | ENSP00000298912 | ENSP00000276708 | Calmin | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.475 |
| CLMN | UPK3A | ENSP00000298912 | ENSP00000216211 | Calmin | Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) | 0.490 |
| CXorf36 | GSDMC | ENSP00000381086 | ENSP00000276708 | Deleted in autism-related protein 1; Chromosome X open reading frame 36 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.610 |
| DFNA5 | GSDMB | ENSP00000339587 | ENSP00000415049 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.514 |
| DFNA5 | GSDMC | ENSP00000339587 | ENSP00000276708 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.572 |
| DFNA5 | TIGD5 | ENSP00000339587 | ENSP00000421489 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Tigger transposable element-derived protein 5; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.575 |
| DFNB59 | GSDMC | ENSP00000386647 | ENSP00000276708 | Pejvakin; Essential in the activity of auditory pathway neurons | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.470 |
| GSDMB | DFNA5 | ENSP00000415049 | ENSP00000339587 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.514 |
| GSDMB | GSDMC | ENSP00000415049 | ENSP00000276708 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.809 |
| GSDMC | C1QTNF9 | ENSP00000276708 | ENSP00000371503 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Complement C1q and tumor necrosis factor-related protein 9A; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity); C1q and TNF related | 0.470 |
| GSDMC | CLMN | ENSP00000276708 | ENSP00000298912 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Calmin | 0.475 |
| GSDMC | CXorf36 | ENSP00000276708 | ENSP00000381086 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Deleted in autism-related protein 1; Chromosome X open reading frame 36 | 0.610 |
| GSDMC | DFNA5 | ENSP00000276708 | ENSP00000339587 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.572 |
| GSDMC | DFNB59 | ENSP00000276708 | ENSP00000386647 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Pejvakin; Essential in the activity of auditory pathway neurons | 0.470 |
| GSDMC | GSDMB | ENSP00000276708 | ENSP00000415049 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.809 |
| GSDMC | ITGA4 | ENSP00000276708 | ENSP00000380227 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions w [...] | 0.647 |
| GSDMC | NBEAL2 | ENSP00000276708 | ENSP00000415034 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis; Armadillo-like helical domain containing | 0.477 |
| GSDMC | TIGD5 | ENSP00000276708 | ENSP00000421489 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Tigger transposable element-derived protein 5; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.570 |
| GSDMC | UPK3A | ENSP00000276708 | ENSP00000216211 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) | 0.488 |
