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  • 11.0 [archived version]
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LSAMP LSAMP ARHGEF33 ARHGEF33 YIPF3 YIPF3 DDC DDC MCC MCC ST18 ST18 PMP2 PMP2 OPALIN OPALIN HIGD1B HIGD1B ZRANB1 ZRANB1 PCMTD1 PCMTD1
"ST18" - Suppression of tumorigenicity 18 protein in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ST18Suppression of tumorigenicity 18 protein; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells; Zinc fingers C2H2C-type (1047 aa)    
Predicted Functional Partners:
OPALIN
Opalin; Oligodendrocytic myelin paranodal and inner loop protein (141 aa)
     
   
  0.624
PMP2
Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family (132 aa)
     
   
  0.575
HIGD1B
HIG1 hypoxia inducible domain family member 1B (99 aa)
     
   
  0.565
MCC
Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and n [...] (1019 aa)
           
  0.554
ARHGEF33
Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor; Rho guanine nucleotide exchange factors (870 aa)
     
   
  0.534
DDC
Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine (480 aa)
     
   
  0.497
ZRANB1
Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes ’Lys-29’-linked and ’Lys-33’- linked diubiquitin. Also cleaves ’Lys-63’-linked chains, but with 40-fold less efficiency compared to ’Lys-29’-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling; Belongs to the peptidase C64 family (708 aa)
           
  0.486
YIPF3
Protein YIPF3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis; Yip1 domain containing (350 aa)
           
  0.476
PCMTD1
protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family (357 aa)
           
  0.473
LSAMP
Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family (338 aa)
     
   
  0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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