| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BBOX1 | CMYA5 | ENSP00000263182 | ENSP00000394770 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | 0.499 |
| BBOX1 | POLR3A | ENSP00000263182 | ENSP00000361446 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | 0.503 |
| BBOX1 | TRAT1 | ENSP00000263182 | ENSP00000295756 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.880 |
| BBOX1 | TRIM46 | ENSP00000263182 | ENSP00000334657 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration; Belongs to the TRIM/RBCC family | 0.449 |
| BBOX1 | TRIM66 | ENSP00000263182 | ENSP00000384876 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Tripartite motif-containing protein 66; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity); Bromodomain containing | 0.502 |
| BBOX1 | TRIM7 | ENSP00000263182 | ENSP00000274773 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.632 |
| C16orf13 | C17orf59 | ENSP00000440765 | ENSP00000373669 | Methyltransferase-like 26; Chromosome 16 open reading frame 13 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor; Belongs to the BORCS6 family | 0.653 |
| C16orf13 | TRIM7 | ENSP00000440765 | ENSP00000274773 | Methyltransferase-like 26; Chromosome 16 open reading frame 13 | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.571 |
| C17orf59 | C16orf13 | ENSP00000373669 | ENSP00000440765 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor; Belongs to the BORCS6 family | Methyltransferase-like 26; Chromosome 16 open reading frame 13 | 0.653 |
| C17orf59 | TRIM7 | ENSP00000373669 | ENSP00000274773 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor; Belongs to the BORCS6 family | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.535 |
| CMYA5 | BBOX1 | ENSP00000394770 | ENSP00000263182 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.499 |
| CMYA5 | TRAT1 | ENSP00000394770 | ENSP00000295756 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.416 |
| CMYA5 | TRIM7 | ENSP00000394770 | ENSP00000274773 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.610 |
| GYG1 | TRAT1 | ENSP00000340736 | ENSP00000295756 | Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase; Glycosyltransferase family 8 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.468 |
| GYG1 | TRIM7 | ENSP00000340736 | ENSP00000274773 | Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase; Glycosyltransferase family 8 | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.870 |
| LRRC57 | TRIM7 | ENSP00000326817 | ENSP00000274773 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.528 |
| POLR3A | BBOX1 | ENSP00000361446 | ENSP00000263182 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.503 |
| POLR3A | TRIM7 | ENSP00000361446 | ENSP00000274773 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation; Belongs to the TRIM/RBCC family | 0.671 |
| TRAT1 | BBOX1 | ENSP00000295756 | ENSP00000263182 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.880 |
| TRAT1 | CMYA5 | ENSP00000295756 | ENSP00000394770 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity); A-kinase anchoring proteins | 0.416 |
