SPINK7 protein (human) - STRING database

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SPINK7

Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type (85 aa)

Predicted Functional Partners:

SPINK6

0.695

HMBOX1

0.694

SPINK2

0.653

MRPS12

0.612

SPINK13

0.580

C1orf137

0.570

RABL6

0.536

TMPRSS11A

0.525

CCL1

0.508

SPINK5

0.498

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf137	SPINK7	ENSP00000358494	ENSP00000274565	Putative uncharacterized protein C1orf137; Chromosome 1 open reading frame 137	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.570
CCL1	SPINK7	ENSP00000225842	ENSP00000274565	C-C motif chemokine 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8; Belongs to the intercrine beta (chemokine CC) family	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.508
HMBOX1	SPINK7	ENSP00000380516	ENSP00000274565	Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.694
MRPS12	RABL6	ENSP00000384952	ENSP00000360727	Mitochondrial ribosomal protein S12	Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family	0.455
MRPS12	SPINK7	ENSP00000384952	ENSP00000274565	Mitochondrial ribosomal protein S12	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.612
RABL6	MRPS12	ENSP00000360727	ENSP00000384952	Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family	Mitochondrial ribosomal protein S12	0.455
RABL6	SPINK7	ENSP00000360727	ENSP00000274565	Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.536
SPINK13	SPINK6	ENSP00000421048	ENSP00000324870	Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	0.426
SPINK13	SPINK7	ENSP00000421048	ENSP00000274565	Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.580
SPINK2	SPINK5	ENSP00000425961	ENSP00000352936	Serine peptidase inhibitor, Kazal type 2	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	0.706
SPINK2	SPINK6	ENSP00000425961	ENSP00000324870	Serine peptidase inhibitor, Kazal type 2	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	0.731
SPINK2	SPINK7	ENSP00000425961	ENSP00000274565	Serine peptidase inhibitor, Kazal type 2	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.653
SPINK5	SPINK2	ENSP00000352936	ENSP00000425961	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	Serine peptidase inhibitor, Kazal type 2	0.706
SPINK5	SPINK6	ENSP00000352936	ENSP00000324870	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	0.749
SPINK5	SPINK7	ENSP00000352936	ENSP00000274565	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.498
SPINK6	SPINK13	ENSP00000324870	ENSP00000421048	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity); Serine peptidase inhibitors, Kazal type	0.426
SPINK6	SPINK2	ENSP00000324870	ENSP00000425961	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	Serine peptidase inhibitor, Kazal type 2	0.731
SPINK6	SPINK5	ENSP00000324870	ENSP00000352936	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type	0.749
SPINK6	SPINK7	ENSP00000324870	ENSP00000274565	Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	0.695
SPINK7	C1orf137	ENSP00000274565	ENSP00000358494	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type	Putative uncharacterized protein C1orf137; Chromosome 1 open reading frame 137	0.570

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