node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAT3 | METTL1 | ENSP00000332448 | ENSP00000314441 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | 0.784 |
ADAT3 | NSUN2 | ENSP00000332448 | ENSP00000264670 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | 0.786 |
ADAT3 | TRIT1 | ENSP00000332448 | ENSP00000321810 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family | 0.708 |
ADAT3 | TRMT1 | ENSP00000332448 | ENSP00000466967 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family | 0.785 |
ADAT3 | TRMT10A | ENSP00000332448 | ENSP00000273962 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)- methyladenine at position 9 (m1A9) in tRNAs; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family | 0.798 |
ADAT3 | TRMT12 | ENSP00000332448 | ENSP00000329858 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family | 0.624 |
ADAT3 | TRMT5 | ENSP00000332448 | ENSP00000261249 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.678 |
ADAT3 | TRMT6 | ENSP00000332448 | ENSP00000203001 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | 0.777 |
ADAT3 | WDR4 | ENSP00000332448 | ENSP00000381266 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit; Belongs to the WD repeat TRM82 family | 0.887 |
METTL1 | ADAT3 | ENSP00000314441 | ENSP00000332448 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | 0.784 |
METTL1 | NSUN2 | ENSP00000314441 | ENSP00000264670 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | 0.922 |
METTL1 | PUS1 | ENSP00000314441 | ENSP00000365837 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity); Belongs to the tRNA pseudouridine synthase TruA family | 0.811 |
METTL1 | TRIT1 | ENSP00000314441 | ENSP00000321810 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family | 0.779 |
METTL1 | TRMT1 | ENSP00000314441 | ENSP00000466967 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family | 0.941 |
METTL1 | TRMT10A | ENSP00000314441 | ENSP00000273962 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)- methyladenine at position 9 (m1A9) in tRNAs; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family | 0.856 |
METTL1 | TRMT12 | ENSP00000314441 | ENSP00000329858 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family | 0.581 |
METTL1 | TRMT5 | ENSP00000314441 | ENSP00000261249 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.774 |
METTL1 | TRMT6 | ENSP00000314441 | ENSP00000203001 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries | 0.953 |
METTL1 | WDR4 | ENSP00000314441 | ENSP00000381266 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit; Belongs to the WD repeat TRM82 family | 0.999 |
NSUN2 | ADAT3 | ENSP00000264670 | ENSP00000332448 | tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily | 0.786 |