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STRINGSTRING
TM4SF20 TM4SF20 HEATR9 HEATR9 NAA30 NAA30 GDI1 GDI1 SMEK1 SMEK1 TM4SF19 TM4SF19 LEPROTL1 LEPROTL1 HTRA4 HTRA4 CRK CRK SMCO1 SMCO1 TCTEX1D2 TCTEX1D2
"TM4SF19" - Transmembrane 4 L six family member 19 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TM4SF19Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family (209 aa)    
Predicted Functional Partners:
HTRA4
Serine protease HTRA4; Serine protease; PDZ domain containing (476 aa)
            
  0.730
LEPROTL1
Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family (169 aa)
            
  0.729
NAA30
N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate; Belongs to the acetyltransferase family. MAK3 subfamily (362 aa)
            
  0.720
SMEK1
Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family (820 aa)
            
  0.712
TM4SF20
Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] (229 aa)
            
  0.591
GDI1
Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (447 aa)
        
      0.532
HEATR9
Protein HEATR9; Armadillo-like helical domain containing (570 aa)
            
  0.530
SMCO1
Single-pass membrane protein with coiled-coil domains 1 (214 aa)
            
  0.530
TCTEX1D2
Tctex1 domain-containing protein 2; Required for proper retrograde ciliary transport; Belongs to the dynein light chain Tctex-type family (142 aa)
            
  0.517
CRK
Adapter molecule crk; Isoform Crk-II- Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (304 aa)
        
      0.513
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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