NICN1 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

NICN1

Nicolin-1; Nicolin 1 (213 aa)

Predicted Functional Partners:

TTLL1

0.986

TPGS2

0.986

TPGS1

0.982

LRRC49

0.982

C11orf49

0.835

KIAA1841

0.829

TBC1D19

0.829

ZNF77

0.810

SMG8

0.775

SRSF11

0.720

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf49	LRRC49	ENSP00000367878	ENSP00000453273	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	0.914
C11orf49	NICN1	ENSP00000367878	ENSP00000273598	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	Nicolin-1; Nicolin 1	0.835
C11orf49	TPGS2	ENSP00000367878	ENSP00000464780	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	Tubulin polyglutamylase complex subunit 2	0.857
C11orf49	TTLL1	ENSP00000367878	ENSP00000266254	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family	0.822
KIAA1841	LRRC49	ENSP00000385579	ENSP00000453273	Uncharacterized protein KIAA1841; KIAA1841	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	0.851
KIAA1841	NICN1	ENSP00000385579	ENSP00000273598	Uncharacterized protein KIAA1841; KIAA1841	Nicolin-1; Nicolin 1	0.829
KIAA1841	TTLL1	ENSP00000385579	ENSP00000266254	Uncharacterized protein KIAA1841; KIAA1841	Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family	0.874
LRRC49	C11orf49	ENSP00000453273	ENSP00000367878	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	0.914
LRRC49	KIAA1841	ENSP00000453273	ENSP00000385579	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Uncharacterized protein KIAA1841; KIAA1841	0.851
LRRC49	NICN1	ENSP00000453273	ENSP00000273598	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Nicolin-1; Nicolin 1	0.982
LRRC49	SMG8	ENSP00000453273	ENSP00000438748	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome-SURF complex and to suppress SMG1 kinase activity until the ribosome-SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity	0.558
LRRC49	TBC1D19	ENSP00000453273	ENSP00000264866	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s)	0.843
LRRC49	TPGS1	ENSP00000453273	ENSP00000352265	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity)	0.991
LRRC49	TPGS2	ENSP00000453273	ENSP00000464780	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Tubulin polyglutamylase complex subunit 2	0.981
LRRC49	TTLL1	ENSP00000453273	ENSP00000266254	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family	0.983
NICN1	C11orf49	ENSP00000273598	ENSP00000367878	Nicolin-1; Nicolin 1	UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family	0.835
NICN1	KIAA1841	ENSP00000273598	ENSP00000385579	Nicolin-1; Nicolin 1	Uncharacterized protein KIAA1841; KIAA1841	0.829
NICN1	LRRC49	ENSP00000273598	ENSP00000453273	Nicolin-1; Nicolin 1	Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49	0.982
NICN1	SMG8	ENSP00000273598	ENSP00000438748	Nicolin-1; Nicolin 1	Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome-SURF complex and to suppress SMG1 kinase activity until the ribosome-SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity	0.775
NICN1	SRSF11	ENSP00000273598	ENSP00000359988	Nicolin-1; Nicolin 1	Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing; RNA binding motif containing	0.720

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