| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C21orf58 | LRTM1 | ENSP00000291691 | ENSP00000273286 | Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58 | Leucine rich repeats and transmembrane domains 1 | 0.478 |
| CACNA2D3 | LRTM1 | ENSP00000419101 | ENSP00000273286 | Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity); Calcium voltage-gated channel auxiliary alpha2delta subunits | Leucine rich repeats and transmembrane domains 1 | 0.491 |
| FOXB2 | LRTM1 | ENSP00000365898 | ENSP00000273286 | Forkhead box protein B2; Transcription factor; Forkhead boxes | Leucine rich repeats and transmembrane domains 1 | 0.668 |
| IGSF8 | LRTM1 | ENSP00000357065 | ENSP00000273286 | Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility- suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the [...] | Leucine rich repeats and transmembrane domains 1 | 0.483 |
| IMMP2L | LRTM1 | ENSP00000384966 | ENSP00000273286 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | Leucine rich repeats and transmembrane domains 1 | 0.490 |
| LPHN1 | LRTM1 | ENSP00000340688 | ENSP00000273286 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine rich repeats and transmembrane domains 1 | 0.685 |
| LPHN2 | LRTM1 | ENSP00000322270 | ENSP00000273286 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine rich repeats and transmembrane domains 1 | 0.747 |
| LPHN3 | LRTM1 | ENSP00000422533 | ENSP00000273286 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine rich repeats and transmembrane domains 1 | 0.685 |
| LRTM1 | C21orf58 | ENSP00000273286 | ENSP00000291691 | Leucine rich repeats and transmembrane domains 1 | Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58 | 0.478 |
| LRTM1 | CACNA2D3 | ENSP00000273286 | ENSP00000419101 | Leucine rich repeats and transmembrane domains 1 | Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity); Calcium voltage-gated channel auxiliary alpha2delta subunits | 0.491 |
| LRTM1 | FOXB2 | ENSP00000273286 | ENSP00000365898 | Leucine rich repeats and transmembrane domains 1 | Forkhead box protein B2; Transcription factor; Forkhead boxes | 0.668 |
| LRTM1 | IGSF8 | ENSP00000273286 | ENSP00000357065 | Leucine rich repeats and transmembrane domains 1 | Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility- suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the [...] | 0.483 |
| LRTM1 | IMMP2L | ENSP00000273286 | ENSP00000384966 | Leucine rich repeats and transmembrane domains 1 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | 0.490 |
| LRTM1 | LPHN1 | ENSP00000273286 | ENSP00000340688 | Leucine rich repeats and transmembrane domains 1 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
| LRTM1 | LPHN2 | ENSP00000273286 | ENSP00000322270 | Leucine rich repeats and transmembrane domains 1 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.747 |
| LRTM1 | LPHN3 | ENSP00000273286 | ENSP00000422533 | Leucine rich repeats and transmembrane domains 1 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.685 |
| LRTM1 | PLEKHA4 | ENSP00000273286 | ENSP00000263265 | Leucine rich repeats and transmembrane domains 1 | Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides; Pleckstrin homology domain containing | 0.503 |
| LRTM1 | RCCD1 | ENSP00000273286 | ENSP00000377801 | Leucine rich repeats and transmembrane domains 1 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.504 |
| PLEKHA4 | LRTM1 | ENSP00000263265 | ENSP00000273286 | Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides; Pleckstrin homology domain containing | Leucine rich repeats and transmembrane domains 1 | 0.503 |
| RCCD1 | LRTM1 | ENSP00000377801 | ENSP00000273286 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Leucine rich repeats and transmembrane domains 1 | 0.504 |
