node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | ARSB | ENSP00000216124 | ENSP00000264914 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | 0.936 |
ARSA | ARSD | ENSP00000216124 | ENSP00000370546 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase D; Sulfatases | 0.922 |
ARSA | ARSE | ENSP00000216124 | ENSP00000441417 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | 0.916 |
ARSA | ARSF | ENSP00000216124 | ENSP00000370519 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase F; Sulfatases | 0.919 |
ARSA | ARSG | ENSP00000216124 | ENSP00000407193 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate; Sulfatases | 0.921 |
ARSA | ARSH | ENSP00000216124 | ENSP00000370522 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase family member H; Sulfatases | 0.924 |
ARSA | ARSI | ENSP00000216124 | ENSP00000333395 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Sulfatases | 0.920 |
ARSA | ARSJ | ENSP00000216124 | ENSP00000320219 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase family member J; Sulfatases | 0.920 |
ARSA | STS | ENSP00000216124 | ENSP00000217961 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases | 0.917 |
ARSA | SUMF1 | ENSP00000216124 | ENSP00000272902 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.980 |
ARSB | ARSA | ENSP00000264914 | ENSP00000216124 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.936 |
ARSB | ARSD | ENSP00000264914 | ENSP00000370546 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase D; Sulfatases | 0.937 |
ARSB | ARSE | ENSP00000264914 | ENSP00000441417 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | 0.933 |
ARSB | ARSF | ENSP00000264914 | ENSP00000370519 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase F; Sulfatases | 0.934 |
ARSB | ARSG | ENSP00000264914 | ENSP00000407193 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate; Sulfatases | 0.923 |
ARSB | ARSH | ENSP00000264914 | ENSP00000370522 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase family member H; Sulfatases | 0.941 |
ARSB | ARSI | ENSP00000264914 | ENSP00000333395 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Sulfatases | 0.903 |
ARSB | ARSJ | ENSP00000264914 | ENSP00000320219 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase family member J; Sulfatases | 0.903 |
ARSB | STS | ENSP00000264914 | ENSP00000217961 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases | 0.934 |
ARSB | SUMF1 | ENSP00000264914 | ENSP00000272902 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.976 |