node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS13 | ADAMTS15 | ENSP00000360997 | ENSP00000299164 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | ADAM metallopeptidase with thrombospondin type 1 motif 15 | 0.922 |
ADAMTS13 | ADAMTS18 | ENSP00000360997 | ENSP00000282849 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | ADAM metallopeptidase with thrombospondin type 1 motif 18 | 0.918 |
ADAMTS13 | ADAMTS9 | ENSP00000360997 | ENSP00000418735 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-|-Ala-1839’ site) and versican (at the ’1428- Glu-|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif | 0.924 |
ADAMTS13 | ADAMTSL1 | ENSP00000360997 | ENSP00000369921 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | ADAMTS-like protein 1; I-set domain containing; ADAMTS like | 0.925 |
ADAMTS13 | SEMA5A | ENSP00000360997 | ENSP00000371936 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...] | 0.900 |
ADAMTS13 | SEMA5B | ENSP00000360997 | ENSP00000389588 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Semaphorin-5B; May act as positive axonal guidance cues; Semaphorins | 0.900 |
ADAMTS13 | SPON1 | ENSP00000360997 | ENSP00000460236 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell | 0.925 |
ADAMTS13 | SPON2 | ENSP00000360997 | ENSP00000483599 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) | 0.904 |
ADAMTS13 | THSD7A | ENSP00000360997 | ENSP00000406482 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism | 0.913 |
ADAMTS13 | THSD7B | ENSP00000360997 | ENSP00000272643 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.913 |
ADAMTS15 | ADAMTS13 | ENSP00000299164 | ENSP00000360997 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif | 0.922 |
ADAMTS15 | ADAMTS18 | ENSP00000299164 | ENSP00000282849 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | ADAM metallopeptidase with thrombospondin type 1 motif 18 | 0.914 |
ADAMTS15 | ADAMTS9 | ENSP00000299164 | ENSP00000418735 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-|-Ala-1839’ site) and versican (at the ’1428- Glu-|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif | 0.911 |
ADAMTS15 | ADAMTSL1 | ENSP00000299164 | ENSP00000369921 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | ADAMTS-like protein 1; I-set domain containing; ADAMTS like | 0.921 |
ADAMTS15 | SEMA5A | ENSP00000299164 | ENSP00000371936 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...] | 0.900 |
ADAMTS15 | SEMA5B | ENSP00000299164 | ENSP00000389588 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Semaphorin-5B; May act as positive axonal guidance cues; Semaphorins | 0.900 |
ADAMTS15 | SPON1 | ENSP00000299164 | ENSP00000460236 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell | 0.909 |
ADAMTS15 | SPON2 | ENSP00000299164 | ENSP00000483599 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) | 0.904 |
ADAMTS15 | THSD7A | ENSP00000299164 | ENSP00000406482 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism | 0.902 |
ADAMTS15 | THSD7B | ENSP00000299164 | ENSP00000272643 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.904 |