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  • 11.0 [archived version]
STRINGSTRING
ADAMTS15 ADAMTS15 SPON1 SPON1 SEMA5B SEMA5B THSD7A THSD7A ADAMTS9 ADAMTS9 SPON2 SPON2 ADAMTS18 ADAMTS18 THSD7B THSD7B SEMA5A SEMA5A ADAMTSL1 ADAMTSL1 ADAMTS13 ADAMTS13
"THSD7B" - Thrombospondin type-1 domain-containing protein 7B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
THSD7BThrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B (1608 aa)    
Predicted Functional Partners:
ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metallopeptidases with thrombospondin type 1 motif (1427 aa)
         
  0.913
SEMA5A
Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...] (1074 aa)
     
 
0.909
SPON1
Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell (807 aa)
     
 
0.905
SEMA5B
Semaphorin-5B; May act as positive axonal guidance cues; Semaphorins (1205 aa)
     
 
0.905
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15 (950 aa)
     
 
    0.904
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif 18 (1221 aa)
     
 
0.904
THSD7A
Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa)
     
 
 
0.904
SPON2
Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS) (331 aa)
     
 
0.902
ADAMTSL1
ADAMTS-like protein 1; I-set domain containing; ADAMTS like (1762 aa)
     
 
 
0.902
ADAMTS9
A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the ’1838-Glu-|-Ala-1839’ site) and versican (at the ’1428- Glu-|-Ala-1429’ site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif (1935 aa)
     
 
 
0.902
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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