| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CKS1B | LAPTM4B | ENSP00000311083 | ENSP00000402301 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | 0.587 |
| CKS1B | LRRC3C | ENSP00000311083 | ENSP00000367157 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.428 |
| CKS1B | NXPH2 | ENSP00000311083 | ENSP00000272641 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.610 |
| CKS1B | SPOPL | ENSP00000311083 | ENSP00000280098 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | Speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes [...] | 0.549 |
| CKS1B | TMEM86A | ENSP00000311083 | ENSP00000280734 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.684 |
| FAM24B | NXPH2 | ENSP00000357894 | ENSP00000272641 | Protein FAM24B; Family with sequence similarity 24 member B | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.558 |
| LAPTM4B | CKS1B | ENSP00000402301 | ENSP00000311083 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.587 |
| LAPTM4B | LRRC3C | ENSP00000402301 | ENSP00000367157 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.554 |
| LAPTM4B | NXPH2 | ENSP00000402301 | ENSP00000272641 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.568 |
| LAPTM4B | TMEM86A | ENSP00000402301 | ENSP00000280734 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.656 |
| LPHN1 | LRRC3C | ENSP00000340688 | ENSP00000367157 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.703 |
| LPHN1 | NRXN1 | ENSP00000340688 | ENSP00000385142 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.530 |
| LPHN1 | NXPE4 | ENSP00000340688 | ENSP00000364627 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family | 0.548 |
| LPHN1 | NXPH2 | ENSP00000340688 | ENSP00000272641 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.556 |
| LRRC3C | CKS1B | ENSP00000367157 | ENSP00000311083 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function | 0.428 |
| LRRC3C | LAPTM4B | ENSP00000367157 | ENSP00000402301 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | 0.554 |
| LRRC3C | LPHN1 | ENSP00000367157 | ENSP00000340688 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.703 |
| LRRC3C | NXPH2 | ENSP00000367157 | ENSP00000272641 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.600 |
| LRRC3C | TMEM86A | ENSP00000367157 | ENSP00000280734 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.775 |
| NPS | NRXN1 | ENSP00000381105 | ENSP00000385142 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.506 |
