| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1QTNF3 | MALL | ENSP00000371497 | ENSP00000272462 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | 0.747 |
| C1QTNF3 | NPHP1 | ENSP00000371497 | ENSP00000313169 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | 0.539 |
| C3 | CD59 | ENSP00000245907 | ENSP00000379191 | Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates; C3 and PZP like, alpha-2-macroglobulin domain containing | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | 0.707 |
| C3 | MALL | ENSP00000245907 | ENSP00000272462 | Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates; C3 and PZP like, alpha-2-macroglobulin domain containing | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | 0.511 |
| CAV1 | CD59 | ENSP00000339191 | ENSP00000379191 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | 0.611 |
| CAV1 | MALL | ENSP00000339191 | ENSP00000272462 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | 0.630 |
| CD59 | C3 | ENSP00000379191 | ENSP00000245907 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates; C3 and PZP like, alpha-2-macroglobulin domain containing | 0.707 |
| CD59 | CAV1 | ENSP00000379191 | ENSP00000339191 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | 0.611 |
| CD59 | MALL | ENSP00000379191 | ENSP00000272462 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | 0.603 |
| CD59 | TPD52 | ENSP00000379191 | ENSP00000429309 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | Tumor protein D52 | 0.540 |
| MALL | C1QTNF3 | ENSP00000272462 | ENSP00000371497 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3 | 0.747 |
| MALL | C3 | ENSP00000272462 | ENSP00000245907 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates; C3 and PZP like, alpha-2-macroglobulin domain containing | 0.511 |
| MALL | CAV1 | ENSP00000272462 | ENSP00000339191 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | 0.630 |
| MALL | CD59 | ENSP00000272462 | ENSP00000379191 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase; Blood group antigens | 0.603 |
| MALL | NPHP1 | ENSP00000272462 | ENSP00000313169 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | 0.714 |
| MALL | OSBPL5 | ENSP00000272462 | ENSP00000263650 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane- specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholestero [...] | 0.585 |
| MALL | PLLP | ENSP00000272462 | ENSP00000219207 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family | 0.543 |
| MALL | RGPD6 | ENSP00000272462 | ENSP00000330842 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | RANBP2-like and GRIP domain-containing protein 5/6; Tetratricopeptide repeat domain containing | 0.530 |
| MALL | TPD52 | ENSP00000272462 | ENSP00000429309 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Tumor protein D52 | 0.574 |
| MALL | TPD52L2 | ENSP00000272462 | ENSP00000217121 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family | Tumor protein D52 like 2 | 0.757 |
