PLEKHA6 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PLEKHA6

Pleckstrin homology domain containing A6 (1048 aa)

Predicted Functional Partners:

GOLT1A

0.878

MYBPHL

0.761

ETNK2

0.731

PPP1R15B

0.730

KCNC4

0.726

PIH1D1

0.716

ALDH16A1

0.708

PIK3C2B

0.658

PPFIA4

0.633

GOLT1B

0.625

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH16A1	ETNK2	ENSP00000293350	ENSP00000356169	Aldehyde dehydrogenase 16 family member A1	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	0.666
ALDH16A1	GOLT1A	ENSP00000293350	ENSP00000308535	Aldehyde dehydrogenase 16 family member A1	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.678
ALDH16A1	GOLT1B	ENSP00000293350	ENSP00000229314	Aldehyde dehydrogenase 16 family member A1	Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.423
ALDH16A1	KCNC4	ENSP00000293350	ENSP00000358802	Aldehyde dehydrogenase 16 family member A1	Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Potassium voltage-gated channels	0.469
ALDH16A1	PIH1D1	ENSP00000293350	ENSP00000262265	Aldehyde dehydrogenase 16 family member A1	PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex; Belongs to the PIH1 family	0.806
ALDH16A1	PIK3C2B	ENSP00000293350	ENSP00000356155	Aldehyde dehydrogenase 16 family member A1	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family	0.629
ALDH16A1	PLEKHA6	ENSP00000293350	ENSP00000272203	Aldehyde dehydrogenase 16 family member A1	Pleckstrin homology domain containing A6	0.708
ALDH16A1	PPP1R15B	ENSP00000293350	ENSP00000356156	Aldehyde dehydrogenase 16 family member A1	Protein phosphatase 1 regulatory subunit 15B; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1; Belongs to the PPP1R15 family	0.421
ETNK2	ALDH16A1	ENSP00000356169	ENSP00000293350	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Aldehyde dehydrogenase 16 family member A1	0.666
ETNK2	GOLT1A	ENSP00000356169	ENSP00000308535	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.760
ETNK2	GOLT1B	ENSP00000356169	ENSP00000229314	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	0.595
ETNK2	PIH1D1	ENSP00000356169	ENSP00000262265	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex; Belongs to the PIH1 family	0.703
ETNK2	PIK3C2B	ENSP00000356169	ENSP00000356155	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family	0.728
ETNK2	PLEKHA6	ENSP00000356169	ENSP00000272203	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Pleckstrin homology domain containing A6	0.731
GOLT1A	ALDH16A1	ENSP00000308535	ENSP00000293350	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Aldehyde dehydrogenase 16 family member A1	0.678
GOLT1A	ETNK2	ENSP00000308535	ENSP00000356169	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	0.760
GOLT1A	KCNC4	ENSP00000308535	ENSP00000358802	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Potassium voltage-gated channels	0.735
GOLT1A	PIH1D1	ENSP00000308535	ENSP00000262265	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex; Belongs to the PIH1 family	0.706
GOLT1A	PIK3C2B	ENSP00000308535	ENSP00000356155	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family	0.797
GOLT1A	PLEKHA6	ENSP00000308535	ENSP00000272203	Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex	Pleckstrin homology domain containing A6	0.878

page 1 of 4

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About