node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf35 | FAM133A | ENSP00000272139 | ENSP00000318974 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Protein FAM133A; Family with sequence similarity 133 member A | 0.689 |
C1orf35 | GUK1 | ENSP00000272139 | ENSP00000355689 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.648 |
C1orf35 | MRPL55 | ENSP00000272139 | ENSP00000403614 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Mitochondrial ribosomal protein L55 | 0.673 |
C1orf35 | PRKRA | ENSP00000272139 | ENSP00000318176 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity i [...] | 0.742 |
C1orf35 | PRPF19 | ENSP00000272139 | ENSP00000227524 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.736 |
C1orf35 | RBM34 | ENSP00000272139 | ENSP00000386226 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | RNA-binding protein 34; RNA binding motif containing; Belongs to the RRM RBM34 family | 0.843 |
C1orf35 | RBMX2 | ENSP00000272139 | ENSP00000339090 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | RNA binding motif protein, X-linked 2 | 0.808 |
C1orf35 | SCARA5 | ENSP00000272139 | ENSP00000346990 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the [...] | 0.651 |
C1orf35 | SLC2A13 | ENSP00000272139 | ENSP00000280871 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family | 0.731 |
C1orf35 | TARBP2 | ENSP00000272139 | ENSP00000266987 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.742 |
FAM133A | C1orf35 | ENSP00000318974 | ENSP00000272139 | Protein FAM133A; Family with sequence similarity 133 member A | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.689 |
FAM133A | RBMX2 | ENSP00000318974 | ENSP00000339090 | Protein FAM133A; Family with sequence similarity 133 member A | RNA binding motif protein, X-linked 2 | 0.818 |
GUK1 | C1orf35 | ENSP00000355689 | ENSP00000272139 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.648 |
GUK1 | MRPL55 | ENSP00000355689 | ENSP00000403614 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | Mitochondrial ribosomal protein L55 | 0.560 |
GUK1 | SCARA5 | ENSP00000355689 | ENSP00000346990 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the [...] | 0.432 |
MRPL55 | C1orf35 | ENSP00000403614 | ENSP00000272139 | Mitochondrial ribosomal protein L55 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.673 |
MRPL55 | GUK1 | ENSP00000403614 | ENSP00000355689 | Mitochondrial ribosomal protein L55 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP | 0.560 |
PRKRA | C1orf35 | ENSP00000318176 | ENSP00000272139 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity i [...] | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.742 |
PRKRA | TARBP2 | ENSP00000318176 | ENSP00000266987 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity i [...] | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] | 0.980 |
PRPF19 | C1orf35 | ENSP00000227524 | ENSP00000272139 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 | 0.736 |