CAPN9 protein (human) - STRING database

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Score

CAPN9

Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family (690 aa)

Predicted Functional Partners:

CAST

0.945

EVPL

0.917

CAPNS1

0.914

CAPNS2

0.909

GKN1

0.901

CLDN23

0.815

PPL

0.765

ZNF185

0.738

AHNAK

0.701

CASP3

0.670

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK	CAPN9	ENSP00000367263	ENSP00000271971	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	0.701
AHNAK	EVPL	ENSP00000367263	ENSP00000301607	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.916
AHNAK	PPL	ENSP00000367263	ENSP00000340510	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family	0.878
AHNAK	ZNF185	ENSP00000367263	ENSP00000440847	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing	0.837
CAPN9	AHNAK	ENSP00000271971	ENSP00000367263	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing	0.701
CAPN9	CAPNS1	ENSP00000271971	ENSP00000246533	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	0.914
CAPN9	CAPNS2	ENSP00000271971	ENSP00000400882	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing	0.909
CAPN9	CASP3	ENSP00000271971	ENSP00000311032	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Caspase-3; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-\|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage	0.670
CAPN9	CAST	ENSP00000271971	ENSP00000379157	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family	0.945
CAPN9	CLDN23	ENSP00000271971	ENSP00000428780	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.815
CAPN9	EVPL	ENSP00000271971	ENSP00000301607	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins	0.917
CAPN9	GKN1	ENSP00000271971	ENSP00000367172	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing	0.901
CAPN9	PPL	ENSP00000271971	ENSP00000340510	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling; Belongs to the plakin or cytolinker family	0.765
CAPN9	ZNF185	ENSP00000271971	ENSP00000440847	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing	0.738
CAPNS1	CAPN9	ENSP00000246533	ENSP00000271971	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	0.914
CAPNS1	CAPNS2	ENSP00000246533	ENSP00000400882	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing	0.920
CAPNS1	CAST	ENSP00000246533	ENSP00000379157	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family	0.982
CAPNS2	CAPN9	ENSP00000400882	ENSP00000271971	Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing	Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family	0.909
CAPNS2	CAPNS1	ENSP00000400882	ENSP00000246533	Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing	Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing	0.920
CAPNS2	CAST	ENSP00000400882	ENSP00000379157	Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing	Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family	0.980

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