CRNN protein (human) - STRING database

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CRNN

Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family (495 aa)

Predicted Functional Partners:

C10orf10

0.931

KPRP

0.691

CRCT1

0.660

SNTN

0.652

LCE3C

0.652

PGLYRP3

0.647

SPRR3

0.646

CNFN

0.628

S100A11

0.623

RT14

0.588

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf10	CRNN	ENSP00000298295	ENSP00000271835	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.931
CNFN	CRCT1	ENSP00000222032	ENSP00000357779	Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia	Cysteine rich C-terminal 1	0.463
CNFN	CRNN	ENSP00000222032	ENSP00000271835	Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.628
CNFN	SPRR3	ENSP00000222032	ENSP00000330391	Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia	Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins	0.512
CRCT1	CNFN	ENSP00000357779	ENSP00000222032	Cysteine rich C-terminal 1	Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia	0.463
CRCT1	CRNN	ENSP00000357779	ENSP00000271835	Cysteine rich C-terminal 1	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.660
CRCT1	KPRP	ENSP00000357779	ENSP00000475216	Cysteine rich C-terminal 1	Keratinocyte proline rich protein	0.404
CRCT1	SPRR3	ENSP00000357779	ENSP00000330391	Cysteine rich C-terminal 1	Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins	0.702
CRNN	C10orf10	ENSP00000271835	ENSP00000298295	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	0.931
CRNN	CNFN	ENSP00000271835	ENSP00000222032	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia	0.628
CRNN	CRCT1	ENSP00000271835	ENSP00000357779	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Cysteine rich C-terminal 1	0.660
CRNN	KPRP	ENSP00000271835	ENSP00000475216	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Keratinocyte proline rich protein	0.691
CRNN	LCE3C	ENSP00000271835	ENSP00000334644	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Late cornified envelope protein 3C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family	0.652
CRNN	PGLYRP3	ENSP00000271835	ENSP00000290722	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family	0.647
CRNN	RT14	ENSP00000271835	ENSP00000447650	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Uncharacterized protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphe [...]	0.588
CRNN	S100A11	ENSP00000271835	ENSP00000271638	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family	0.623
CRNN	SNTN	ENSP00000271835	ENSP00000341442	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules	0.652
CRNN	SPRR3	ENSP00000271835	ENSP00000330391	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins	0.646
KPRP	CRCT1	ENSP00000475216	ENSP00000357779	Keratinocyte proline rich protein	Cysteine rich C-terminal 1	0.404
KPRP	CRNN	ENSP00000475216	ENSP00000271835	Keratinocyte proline rich protein	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.691

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