HMCN1 protein (human) - STRING database

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HMCN1

Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins (5635 aa)

Predicted Functional Partners:

FRAS1

0.807

FREM2

0.730

FREM1

0.722

FREM3

0.719

ARMS2

0.719

VWA2

0.589

C2

0.545

PLEKHA1

0.542

RAX2

0.527

CTDSPL

0.520

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMS2	C2	ENSP00000436682	ENSP00000299367	Age-related maculopathy susceptibility 2	Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family	0.790
ARMS2	HMCN1	ENSP00000436682	ENSP00000271588	Age-related maculopathy susceptibility 2	Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins	0.719
ARMS2	PLEKHA1	ENSP00000436682	ENSP00000357986	Age-related maculopathy susceptibility 2	Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane; Pleckstrin homology domain containing	0.804
ARMS2	RAX2	ENSP00000436682	ENSP00000450456	Age-related maculopathy susceptibility 2	Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter; PRD class homeoboxes and pseudogenes	0.499
C2	ARMS2	ENSP00000299367	ENSP00000436682	Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family	Age-related maculopathy susceptibility 2	0.790
C2	HMCN1	ENSP00000299367	ENSP00000271588	Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family	Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins	0.545
C2	PLEKHA1	ENSP00000299367	ENSP00000357986	Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family	Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane; Pleckstrin homology domain containing	0.449
C2	RAX2	ENSP00000299367	ENSP00000450456	Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family	Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter; PRD class homeoboxes and pseudogenes	0.537
CTDSPL	HMCN1	ENSP00000273179	ENSP00000271588	CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of ’Ser-5’ within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation; CTD family phosphatases	Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins	0.520
FRAS1	FREM1	ENSP00000326330	ENSP00000412940	Fraser extracellular matrix complex subunit 1	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	0.583
FRAS1	FREM2	ENSP00000326330	ENSP00000280481	Fraser extracellular matrix complex subunit 1	FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.883
FRAS1	FREM3	ENSP00000326330	ENSP00000332886	Fraser extracellular matrix complex subunit 1	FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion	0.724
FRAS1	HMCN1	ENSP00000326330	ENSP00000271588	Fraser extracellular matrix complex subunit 1	Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins	0.807
FRAS1	VWA2	ENSP00000326330	ENSP00000376708	Fraser extracellular matrix complex subunit 1	Von Willebrand factor A domain containing 2	0.688
FREM1	FRAS1	ENSP00000412940	ENSP00000326330	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	Fraser extracellular matrix complex subunit 1	0.583
FREM1	FREM2	ENSP00000412940	ENSP00000280481	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	0.429
FREM1	HMCN1	ENSP00000412940	ENSP00000271588	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins	0.722
FREM1	VWA2	ENSP00000412940	ENSP00000376708	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	Von Willebrand factor A domain containing 2	0.583
FREM2	FRAS1	ENSP00000280481	ENSP00000326330	FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	Fraser extracellular matrix complex subunit 1	0.883
FREM2	FREM1	ENSP00000280481	ENSP00000412940	FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion	FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family	0.429

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