node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERICH5 | SEL1L3 | ENSP00000315614 | ENSP00000382767 | Glutamate-rich protein 5; Glutamate rich 5 | Protein sel-1 homolog 3; SEL1L family member 3 | 0.481 |
ERICH5 | SLC44A3 | ENSP00000315614 | ENSP00000271227 | Glutamate-rich protein 5; Glutamate rich 5 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.474 |
GDPD1 | PCYT1B | ENSP00000284116 | ENSP00000368439 | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis | 0.694 |
GDPD1 | SLC44A3 | ENSP00000284116 | ENSP00000271227 | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.549 |
GDPD1 | SLC5A7 | ENSP00000284116 | ENSP00000264047 | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.511 |
HUNK | SLC44A3 | ENSP00000270112 | ENSP00000271227 | Hormonally up-regulated Neu-associated kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.447 |
HUNK | THADA | ENSP00000270112 | ENSP00000385995 | Hormonally up-regulated Neu-associated kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily | Thyroid adenoma-associated protein; THADA, armadillo repeat containing; Belongs to the THADA family | 0.457 |
IMPA2 | SLC44A3 | ENSP00000269159 | ENSP00000271227 | Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.548 |
PCYT1B | GDPD1 | ENSP00000368439 | ENSP00000284116 | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | 0.694 |
PCYT1B | SLC44A3 | ENSP00000368439 | ENSP00000271227 | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.437 |
PCYT1B | SLC5A7 | ENSP00000368439 | ENSP00000264047 | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.411 |
SEL1L3 | ERICH5 | ENSP00000382767 | ENSP00000315614 | Protein sel-1 homolog 3; SEL1L family member 3 | Glutamate-rich protein 5; Glutamate rich 5 | 0.481 |
SEL1L3 | SLC44A3 | ENSP00000382767 | ENSP00000271227 | Protein sel-1 homolog 3; SEL1L family member 3 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.454 |
SEL1L3 | TMEM82 | ENSP00000382767 | ENSP00000364938 | Protein sel-1 homolog 3; SEL1L family member 3 | Transmembrane protein 82 | 0.455 |
SLC39A2 | SLC44A3 | ENSP00000298681 | ENSP00000271227 | Zinc transporter ZIP2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis; Solute carriers | Choline transporter-like protein 3; Solute carrier family 44 member 3 | 0.428 |
SLC44A3 | ERICH5 | ENSP00000271227 | ENSP00000315614 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | Glutamate-rich protein 5; Glutamate rich 5 | 0.474 |
SLC44A3 | GDPD1 | ENSP00000271227 | ENSP00000284116 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | 0.549 |
SLC44A3 | HUNK | ENSP00000271227 | ENSP00000270112 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | Hormonally up-regulated Neu-associated kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily | 0.447 |
SLC44A3 | IMPA2 | ENSP00000271227 | ENSP00000269159 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain | 0.548 |
SLC44A3 | PCYT1B | ENSP00000271227 | ENSP00000368439 | Choline transporter-like protein 3; Solute carrier family 44 member 3 | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis | 0.437 |