node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AJAP1 | HS3ST2 | ENSP00000367433 | ENSP00000261374 | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate | 0.499 |
AJAP1 | ZNF614 | ENSP00000367433 | ENSP00000270649 | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.545 |
B4GALNT4 | SYNDIG1L | ENSP00000328277 | ENSP00000331474 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | 0.592 |
B4GALNT4 | ZNF614 | ENSP00000328277 | ENSP00000270649 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.510 |
GRM4 | SYNDIG1L | ENSP00000440556 | ENSP00000331474 | Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | 0.455 |
GRM4 | ZNF614 | ENSP00000440556 | ENSP00000270649 | Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.527 |
HS3ST2 | AJAP1 | ENSP00000261374 | ENSP00000367433 | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration | 0.499 |
HS3ST2 | ZNF614 | ENSP00000261374 | ENSP00000270649 | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.513 |
LRRC48 | ZNF614 | ENSP00000382140 | ENSP00000270649 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.481 |
POU4F3 | SOX8 | ENSP00000230732 | ENSP00000293894 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5’-ATGCAAAT-3’ in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity); Belongs to the POU transcription factor family. Class- 4 subfamily | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5’-[AT][AT]CAA[AT]G-3’ (By similarity); SRY-boxes | 0.469 |
POU4F3 | ZNF614 | ENSP00000230732 | ENSP00000270649 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5’-ATGCAAAT-3’ in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity); Belongs to the POU transcription factor family. Class- 4 subfamily | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.494 |
SOX8 | POU4F3 | ENSP00000293894 | ENSP00000230732 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5’-[AT][AT]CAA[AT]G-3’ (By similarity); SRY-boxes | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5’-ATGCAAAT-3’ in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity); Belongs to the POU transcription factor family. Class- 4 subfamily | 0.469 |
SOX8 | ZNF614 | ENSP00000293894 | ENSP00000270649 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5’-[AT][AT]CAA[AT]G-3’ (By similarity); SRY-boxes | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.489 |
SYNDIG1L | B4GALNT4 | ENSP00000331474 | ENSP00000328277 | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family | 0.592 |
SYNDIG1L | GRM4 | ENSP00000331474 | ENSP00000440556 | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | 0.455 |
SYNDIG1L | VRTN | ENSP00000331474 | ENSP00000256362 | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | Vertnin; Vertebrae development associated; Belongs to the vertnin family | 0.753 |
SYNDIG1L | ZNF614 | ENSP00000331474 | ENSP00000270649 | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.644 |
TRIM28 | ZNF614 | ENSP00000253024 | ENSP00000270649 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.903 |
VRTN | SYNDIG1L | ENSP00000256362 | ENSP00000331474 | Vertnin; Vertebrae development associated; Belongs to the vertnin family | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing | 0.753 |
VRTN | ZNF614 | ENSP00000256362 | ENSP00000270649 | Vertnin; Vertebrae development associated; Belongs to the vertnin family | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.597 |