| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FBXO47 | IMMP1L | ENSP00000367319 | ENSP00000278200 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | 0.744 |
| FBXO47 | NOSIP | ENSP00000367319 | ENSP00000470034 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | 0.595 |
| FBXO47 | PRRG2 | ENSP00000367319 | ENSP00000246794 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.550 |
| FBXO47 | RCN3 | ENSP00000367319 | ENSP00000270645 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.480 |
| FCGRT | RCN3 | ENSP00000221466 | ENSP00000270645 | IgG receptor FcRn large subunit p51; Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.448 |
| FKBP9 | RCN3 | ENSP00000439250 | ENSP00000270645 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.455 |
| IMMP1L | FBXO47 | ENSP00000278200 | ENSP00000367319 | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.744 |
| IMMP1L | NOSIP | ENSP00000278200 | ENSP00000470034 | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | 0.643 |
| IMMP1L | PRRG2 | ENSP00000278200 | ENSP00000246794 | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.544 |
| IMMP1L | RCN3 | ENSP00000278200 | ENSP00000270645 | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.457 |
| NOSIP | FBXO47 | ENSP00000470034 | ENSP00000367319 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.595 |
| NOSIP | IMMP1L | ENSP00000470034 | ENSP00000278200 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | 0.643 |
| NOSIP | PRRG2 | ENSP00000470034 | ENSP00000246794 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | 0.698 |
| NOSIP | RCN3 | ENSP00000470034 | ENSP00000270645 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.771 |
| PCDHGA12 | RCN3 | ENSP00000252085 | ENSP00000270645 | Protocadherin gamma-A12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.500 |
| PCSK6 | RCN3 | ENSP00000482760 | ENSP00000270645 | Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues; Proprotein convertase subtilisin/kexin family | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.577 |
| PNMAL1 | RCN3 | ENSP00000318131 | ENSP00000270645 | Paraneoplastic antigen-like protein 8A; Paraneoplastic Ma antigen family-like 1 | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.448 |
| PRDX6 | RCN3 | ENSP00000342026 | ENSP00000270645 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family | 0.573 |
| PRRG2 | FBXO47 | ENSP00000246794 | ENSP00000367319 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.550 |
| PRRG2 | IMMP1L | ENSP00000246794 | ENSP00000278200 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO | 0.544 |
