KLHDC4 protein (human) - STRING database

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Score

KLHDC4

Kelch domain containing 4 (520 aa)

Predicted Functional Partners:

POLR1B

0.808

BOP1

0.734

ARMC6

0.728

SDAD1

0.683

BMS1

0.652

KIAA0020

0.640

MAK16

0.639

TMEM261

0.609

BRIX1

0.608

ARMC7

0.603

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC6	KLHDC4	ENSP00000444156	ENSP00000270583	Armadillo repeat containing 6	Kelch domain containing 4	0.728
ARMC7	KLHDC4	ENSP00000245543	ENSP00000270583	Armadillo repeat containing 7	Kelch domain containing 4	0.603
ARMC7	TMEM261	ENSP00000245543	ENSP00000350961	Armadillo repeat containing 7	Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I	0.620
BMS1	BOP1	ENSP00000363642	ENSP00000455106	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	0.994
BMS1	BRIX1	ENSP00000363642	ENSP00000338862	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.930
BMS1	KIAA0020	ENSP00000363642	ENSP00000380982	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.904
BMS1	KLHDC4	ENSP00000363642	ENSP00000270583	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Kelch domain containing 4	0.652
BMS1	MAK16	ENSP00000363642	ENSP00000353246	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Protein MAK16 homolog; RNA binding motif containing	0.940
BMS1	POLR1B	ENSP00000363642	ENSP00000444136	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.893
BMS1	SDAD1	ENSP00000363642	ENSP00000348596	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family	0.913
BOP1	BMS1	ENSP00000455106	ENSP00000363642	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	0.994
BOP1	BRIX1	ENSP00000455106	ENSP00000338862	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.990
BOP1	KIAA0020	ENSP00000455106	ENSP00000380982	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.916
BOP1	KLHDC4	ENSP00000455106	ENSP00000270583	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Kelch domain containing 4	0.734
BOP1	MAK16	ENSP00000455106	ENSP00000353246	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Protein MAK16 homolog; RNA binding motif containing	0.985
BOP1	POLR1B	ENSP00000455106	ENSP00000444136	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.905
BOP1	SDAD1	ENSP00000455106	ENSP00000348596	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family	0.906
BRIX1	BMS1	ENSP00000338862	ENSP00000363642	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus	0.930
BRIX1	BOP1	ENSP00000338862	ENSP00000455106	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	0.990
BRIX1	KIAA0020	ENSP00000338862	ENSP00000380982	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity)	0.982

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